Thyroid dysfunction is common, particularly in the elderly, and has an important impact on morbidity and mortality, especially in this age group.
Aim: We have investigated associations between thyroid function, presence of atrial fibrillation and cognitive function in a large general practice-based study conducted from December 2002-November 2004. Subjects with a previous history of thyroid disease or currently taking thyroxine or anti-thyroid drugs were excluded. We report a preliminary analysis of the data concerning the proportion of subjects with abnormal TSH (measured using a sensitive assay) and fT4 values.
Method: 5784 subjects aged 65 or over had TSH and fT4 measurements performed. The mean age of subjects was 73.5 years; 49.3% male (mean age 73.3), 50.7% female (mean age 73.7). Reference ranges for TSH were 0.4-5.5mU/l and fT4 9-20 pmol/l
Conclusion: in this the largest UK based study of community living subjects of 60 years and over we have demonstrated that a high proportion have both hypothyroidism and hyperthyroidism, especially subclinical disease.
04 - 06 Apr 2005
British Endocrine Societies