Searchable abstracts of presentations at key conferences in endocrinology
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8th European Congress of Endocrinology incorporating the British Endocrine Societies

Plenary Lecturers’ Biographical Notes

Transatlantic Medal Lecture

ea0011s3 | Transatlantic Medal Lecture | ECE2006

Nuclear receptors and transcriptional control of lipid metabolism

Mangelsdorf D

Nuclear receptors are ligand-dependent transcription factors that govern complex physiologic pathways, including reproduction, development, and metabolism. The importance of this receptor superfamily is emphasized by its conservation throughout evolution, from simple multicellular organisms to humans. Because of their therapeutic potential in governing physiology and disease, targeting nuclear receptors for novel drug discovery has become a major interest in both academia and ...