Searchable abstracts of presentations at key conferences in endocrinology
Previous issue | Volume 11 | ECE2006 | Next issue

8th European Congress of Endocrinology incorporating the British Endocrine Societies

ea0011s8 | Vitamin D action | ECE2006

Vitamin D action

Bouillon R

Ligand activated VDR regulates about 3% the mouse genome. Its classical function is to regulate calcium and bone homeostasis. 1,25-(OH)2D is essential for transepithelial calcium transport in the intestine (by an epithelial calcium channel, TRPV6) and in the kidney (TRPV5). Normal osteoclastogenesis and bone resorption as well as bone mineralisation is possible in the absence of VDR when VDR KO men or animals receive a high calcium diet. VDR.1α,25-(OH)2</s...