Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2006) 11 P288

ECE2006 Poster Presentations Diabetes, metabolism and cardiovascular (174 abstracts)

Mortality risks of diabetic patients who reach end stage renal disease (ESRD) in the united states: age and gender differences

AG Stack & L O’Shea


Regional Kidney Centre, Department of Medicine, Letterkenny, General Hospital, Donegal, Ireland.


Prior studies have demonstrated that diabetes as a cause of or contributing factor to end stage renal disease (ESRD) has a detrimental impact on survival. What is unclear is whether this effect varies by age and gender.

Methods: The objective of this study was to evaluate mortality differences by age and gender among diabetic and non-diabetic ESRD patients in a national cohort. Data on all new ESRD patients (n=451,296) who were initiated on dialysis in the U.S. between 5/1995-12/2000 and followed until 12/2001 were obtained from the U.S. Renal Data System. Mortality risks were compared for diabetic and non-diabetic patients using Cox regression adjusting for sociodemographic characteristics and 18 comorbid indicators recorded at ESRD onset. The cohort was stratified by age group (<50, 50–70 and >70 yrs) and gender.

Results: The adjusted relative hazard ratios (RR) for death for Diabetic (DM) vs non-Diabetic (Non-DM) patients are shown.

Adjusted RR of Death (Diabetic vs Non Diabetic)
Group< 50 yrs50–70 yrs> 70 yrs
Non-DMDMNon-DMDMNon-DMDM
All Patients1.001.33**1.001.10**1.001.05*
Male1.001.21**1.001.05*1.001.11 **
Female1.001.51 **1.001.14**1.000.93
*P< 0.01, **P<0.001

Conclusions: Mortality risks were significantly greater in diabetic than non-diabetic ESRD patients. These risks were greatest for patients <50 yrs and females. Whether these differences represent inequalities in delivered diabetic care or greater disease severity deserves further attention.

Volume 11

8th European Congress of Endocrinology incorporating the British Endocrine Societies

European Society of Endocrinology 
British Endocrine Societies 

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