Dyslipidemiαs should be managed from childhood for prevention of early atheromatic vascular lesions and premature cardiovascular disease in adult life.
Aim: We examined the frequency of different types of dyslipidemiα in children and the results on blood lipids of lifestyle intervention (diet and exercise).
Patients and methods: We studied retrospectively 136 children, 74 boys and 62 girls, mean chronological age 8.5±3.5 years with dyslipidemiα. Secondary causes of dyslipidemiα were excluded. High levels were considered for total cholesterol (h-TC) >200 mg%, LDL-cholesterol (h-LDL-c) >130 mg%, triglycerides (h-TG) >100 mg%, HDL-cholesterol (h-HDL-c) >60 mg% and low level for HDL-c (l-HDL-c) <45 mg%. For statistical analyses Mann-Whitney test and Wilcoxon test were used.
Results: The frequency of different types of dyslipidemiα is presented in the table. LDL-c was significantly increased in children with family history of premature cardiovascular disease (FHCD) compared to those without FHCD (178.1±50.4 mg% vs 139.3±33.3 mg%, p<0.002). Fifty-nine children who were reexamined after 0.9±0.9years of lifestyle intervention had significantly decreased levels of LDL-c (158.4±35.1 mg% vs 133.7±25.5 mg%, p<0.001, percentage 13.8%). There was not any significant difference in levels of TG or HDL-c.
Conclusions: Increased LDL-c is the most frequent lipid abnormality among children with dyslipidemias. Low HDL-c, alone or in combination with h-LDL-c or/and h-TG is frequently observed. Lifestyle interventions are effective in significantly decreasing LDL-c.
|Causes of lipid testing (%)||Patients characteristics (%)||Dyslipidaemiαs Frequency (%)|
|Family history of dyslipidemiα||33.1||h-LDL-c & h-HDL-c 29.4||h-LDL-c & h-TG & l-HDL-c 9.6|
|Obesity||36.4||Obesity||23.1||h-LDL-c alone 16.2||h-LDL-c & l-HDL-c 5.9|
|Incidental finding||19.8||Family history of dyslipidaemiα||95.1||h-LDL-c & h-TG 12.5||h-Lp (a) 3.7|
|FHCD||10.7||FHCD||62.3||h-TC & h-HDL-c 11.8||l-HDL-c alone 2.9|
01 - 05 Apr 2006
European Society of Endocrinology