Intracranial germinomas are malignant neoplasms which are supposed to arise from primitive germ cells failed to migrate to the genital crest during embryonic development. Most of them are located in the intra-suprasellar region and may cause anterior and particularly posterior pituitary hormone deficits. Early establishment of the histological diagnosis is important for optimum treatment planning and a successful outcome. Intracranial germinomas are radiosensitive and potentially curable. In this study we report a case of an intrasellar germinomas leading to infundibular thickening with lymphohistiocytic reaction and normal β-HCG concentrations in the cerebrospinal fluid (CSF).
01 - 05 Apr 2006
European Society of Endocrinology