Polycystic ovary syndrome (PCOS), affects approximately 5% to 10% all women. Insulin resistance is highly associated with this syndrome. Insulin resistance is associated with increased oxidation of low density lipoprotein (LDL) cholesterol. Oxidized LDL autoantibody levels are generally measured to evaluate the degree of LDL oxidation. In the present study, we aimed to measure serum titers of oxidized LDL autoantibodies in patients with PCOS.
Twenty-five patients with PCOS, age (mean 27±3.5) and BMI matched healthy women were studied. Serum concentrations of oxidized LDL autoantibodies were determined using an enzyme-linked immunosorbent assay from a commercially available test kit (Biomedica, Vienna, Austria) designed to directly determine human autoantibodies to Cu2 oxidized LDL in serum. Homeostasis model assessment (HOMA-IR) index was used for insulin resistance.
Mean HOMA-IR was higher in the PCOS group than in the control group (respectively, 2.84±1.16 and 1.23±0.58, P<0.001). Oxidized LDL autoantibodies were significantly different in the PCOS group (491±109 mU/ml) than in the control group (268±86 mU/ml) (P<0.001). In the PCOS group, oxidized LDL autoantibody was positively correlated with HOMA-IR (r=0.24. P<0.005).
This study suggests that increased oxidized LDL autoantibodies could contribute to the increased risk of cardiovascular disease in patients with PCOS.
01 - 05 Apr 2006
European Society of Endocrinology