Aim: To estimate efficiency of 200 mkg/day iodine for prevention of development of hypothyroxinemia in pregnant women with non toxic goiter and without it, who were living in region with mild iodine deficiency.
Subjects and methods: Study group consists of 32 pregnant women: 16 with non toxic goiter (8 from them took 200 mkg of iodine), 16 - without thyroid disease (8 from them took 200 mkg of iodine).
Results: Pregnant women with goiter, who took iodine, had lower TSH level and smaller frequency of hypothyroxinemia in 3rd trimester, than pregnant women, who didnt take iodine (TSH 0.8 mU/ml vs 1.8 mU/ml, P<0.05; fT4 less than 10 percentiles 25% vs 87.5%, P<0.05). There wasnt difference between TSH and frequency of hypothyroxinemia in 3rd trimester in healthy pregnant women, who took iodine or didnt take it. But in 2nd trimester fT4 less, than 10 percentiles, was determined in 25% of women without goiter and without iodine and in women with goiter. Nobody of pregnant women without goiter, taking iodine, had hypothyroxinemia in 2nd trimester. The frequency of threat of abortion also was dependent on iodine. It was determined in 50% of pregnant women with goiter taking iodine and 75% without iodine. In pregnant women without goiter the threat of abortion was 28.6% with iodine and 60% without iodine. The weights and highs of offsprings from women taking iodine was some greater, than without iodine.
Conclusions: Addition of 200 mkg of iodine effectively prevent development of hypothyroxinemia in the 2nd trimester in pregnant women without goiter. But pregnant women with non toxic goiter need to higher doses of iodine for notice of hipothyroxinemia in region with mild iodine - deficiency. The iodine had favourable effect on pregnancy and weight and high of offspring.
01 - 05 Apr 2006
European Society of Endocrinology