Endocrine Abstracts (2006) 11 OC24

Low testosterone and atherogenic lipid profile in aging men

JI Mäkinen1, A Perheentupa1, K Irjala1, P Pöllänen1, J Mäkinen1, I Huhtaniemi2 & O Raitakari1

1University of Turku, Turku, Finland; 2Imperial College, London, United Kingdom.

Introduction: Aging men with low testosterone concentration may be at increased risk for cardiovascular disease. In some studies, but not all, low serum testosterone concentration has been associated with an atherogenic serum lipid profile.

Methods: Year 2000 all the men aged 40–70 years (N=28,622) in the city of Turku, Finland, received a questionnaire on andropausal symptoms. Those men who reported high andropausal symptoms were tested for serum testosterone, luteinizing hormone and lipids (triglycerides, total-, LDL- and HDL cholesterol).

Results: A total of 15,991 men answered to the questionnaire. From these men 2,700 had high andropausal symptom score and 1,670 underwent the laboratory tests. The mean age of the men with laboratory data was 55±8 years, serum total cholesterol was 6.2±1.2 mmol/l and serum testosterone15.3±5.4 nmol/l. In bivariate analysis, testosterone correlated directly with HDL-cholesterol (r=0.24, P<0.0001), and inversely with triglycerides (r=−0.29, P<0.0001), body mass index (BMI, r=−0.34, P<0.0001) and total cholesterol (r−0.05, P=0.016). In multivariate analysis, the significant correlates of triglycerides included testosterone, BMI and age (P<0.0001 in all). The correlates of HDL cholesterol included testosterone (P=0.015), smoking (P=0.02) and alcohol consumption (P=0.003).

Conclusion: We conclude that in aging men, low serum testosterone concentration is associated with a potentially atherogenic lipid profile, characterized by low HLD cholesterol and high triglycerides concentrations. These relations are independent of age and BMI status.

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