ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2006) 11 P218

The role of IL-4 and IFN-gamma as prognostic factors of major adverse cardiac events in patients with ST-elevation myocardial infarction assigned primary percutaneous coronary intervention

M Osuch1, B Szygula-Jurkiewicz1, J Szkodzinski1, R Wojnicz1, A Lekston1, L Polonski1, A Blazelonis2 & B Zubelewicz-Szkodzinska2

1Silesian Center for Heart Disease, Zabrze, Poland; 2Silesian Medical University, Bytom, Poland.

Mediators of inflammatory reaction are present at every stage of forming of atheromatous plaque, its proliferation and destabilization. Cytokines play a key role in regulation of intensity of chronic inflamatory reaction. We aimed at investigation if IL-4 and IFN-gamma are predictors of MACE in a group of patients with acute myocardial infarction (AMI).

A total of 50 patients: 40 males and 10 females, aged 56±10 years (mean±S.D.), with diagnosis of AMI, who underwent primary percutaneous coronary intervention (PCI) were analysed. All patients were followed for an average period of 17±5 months. The event rate during follow-up for combined end point (MACE) of death, myocardial infarction and repeated revascularization was assessed. Plasma levels of IFN-gamma and IL-4 measured in venous blood samples, collected before and immediately after successful PCI as well as at the 2nd and 72nd hour after intervention. Patients with MACE (gorup I) were compared with the remaining ones (group II).

In a long-term observation MACE were observed in 6 pts (12%). In the group I plasma levels of IL-4, before PCI procedure were significantly lower (13.4±1.27 pg/ml vs 17.98±3.21 pg/ml, P<0.0001). In this group, plasma levels of IFN-gamma obtained immediately after PCI were significantly higher (12.6 (range 1.8–34.0) pg/ml vs 0.89 (range 0–2.1) pg/ml, P=0.0001) comparing to the IFN-gamma plasma level in the group II.

Initial plasma level of IL-4 proved to be a predictive factor of adverse cardiac events occurrence in patients with acute myocardial infarction undrgoing percutaneous coroanry intervention. Elevated IFN-gamma plasma level measured directy after pecutaneous coronary intervention was an unfavorable predictive factor of adverse cardiac events in patients with acute myocardial infarction.