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Endocrine Abstracts (2006) 11 P275

ECE2006 Poster Presentations Diabetes, metabolism and cardiovascular (174 abstracts)

Hyperlactatidemia caused by acute myocardial infarction in patients with type 2 diabetes mellitus

A Jovanovic , V Peric , S Sovtic , T Novakovic , R Stolic & S Markovic-Jovanovic


University in Kos.Mitrovica, Kosovo&Metohija, Yugoslavia.


Background: Metabolic disturbances could contribute to poor outcome after acute myocardial infarction (AIM) in type 2 diabetic patients.

Objective: We examined the acid base disturbances that could contribute to poor prognosis after MI among type 2 diabetics suffering AMI.

Methods: Parameters of acid base status and blood lactate level were compared (using one and two – way ANOVA) in 160 age-matched individuals. Forty of them were type 2 diabetics in acute phase of MI; 40 were patients with AMI and normal blood glucose, and another 40 were type 2 diabetics with no evidence of CAD; control group consisted of 40 healthy persons. Different clinical metabolic and hormonal influences were examined in multiple correlation analysis.

Results: Blood lactate levels were significantly higher (P<0.01) in type 2 diabetics suffering AIM (DM+AIM) than in other examined groups. Blood lactate levels in DM+AIM group correlated significantly with degree of hearth insufficiency (r=41), hearth rhythm and conduction disturbances (r=0.54), CK level (r=0.68), blood glucose (r=0.46) SaO2 (r=0.68) and serum noradrenalin level (r=0.44).

Conclusion: Incidence of hyperlactatidemia in acute of myocardial infarction in type 2 diabetics is much higher than in non-diabetics with acute myocardial infarction. Stress-related diabetic ketoacidosis occurs less frequently than lactic acidosis in type 2 diabetics suffering AIM.

Volume 11

8th European Congress of Endocrinology incorporating the British Endocrine Societies

European Society of Endocrinology 
British Endocrine Societies 

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