Endocrine Abstracts (2006) 11 P296

Biochemical predictors of the cardiovascular complications in patients with obesity and type 2 diabetes

Tamar Doliashvili, Elen Giorgadze, Nana Tsagareli, Keteva Asatiani & Keteva Bochorishvili

N4 clinical hospital, Tbilisi, Georgia.

Background: The impact of hyperglycemia on atherogenesis is regulated through the increase of the oxidative stress, increase of the rest of the glycosylated products of metabolism and development of the endothelium dysfunction.

Aim: To compare the biochemical indexes and investigate their relationship with the development of cardiovascular disease in obese patients with and without type 2 diabetes.

Materials and methods: 21 patients (mean age 22–65 years) divided in 2 groups were investigated. I group comprised the obese patients with type 2 diabetes documented with clinical data, II group – obese patients without diabetes. In I group 8 patients had extension of heart chambers, 7- diastolic dysfunction of the left ventricle, 3 – hyperthropy of IVS, 7 – ischemic alterations, 6 – arterial hypertension. In II group - 8 patients had extension of heart chambers, 5- diastolic dysfunction of the left ventricle, 7 – hyperthropy of IVS, 3 – ischemic alterations, 2 – arterial hypertension.

Results: Patients with type 2 diabetes had increased BMI. Elevation of Cholesterol, Tryglicerids, LDL and the lowering of HDL was practically equal in both groups. The level of glycosylated hemoglobin in patients with diabetes was elevated what is risk for the development of the cardiovascular diseases.

Conclusions: In both of the groups was the anatomic and functional alteration of the heart observed, although the cardiovascular complications significantly prevail over in patients with type 2 diabetes. In obese patients with diabetes the main damage is disturbance of energetic metabolism in cardyomyocytes, what reduces the ability of the myocard for the functional adaptation and more early clinical manifestation of the cardiovascular diseases.

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