Aims: To calculate the sensitivity, specificity and positive predictive value of Parathyroid scintigraphy using Technetium-Sestamibi scan in the localization of parathyroid disease.
Methods and material: This is a retrospective medical review of 161 patients who underwent the Parathyroid scintigraphy at our hospital in last six years. True positives were defined as patients with confirmed primary hyperparathyroidism (PHPT) on pathological examination. True negatives were patients with negative biochemical evaluation and normal Parathyroid scintigraphy. False positives were patients with positive scans and no biochemical features of PHPT. False negatives were patients with a negative scan and biochemical hyperparathyroidism with a histological diagnosis of PHPT.
Results: The sensitivity of Parathyroid scintigraphy (PS) for precise localization of parathyroid adenoma is 76% with a specificity of 78%. The positive predictive value for Parathyroid scintigraphy (PS) for accurate and unambiguous localization is 84.2%.
Conclusions: 99mTc-Sestamibi remains a valuable tool for localization of preoperative parathyroid disease. In the present clinical setting it may not be sensitive enough to replace bilateral neck exploration with more limited surgical procedures.
01 - 05 Apr 2006
European Society of Endocrinology