Endocrine Abstracts (2006) 11 P447

Pituitary tumors in republic of Croatia

M Vrkljan1, A Maric1, M Matovinovic1, V Cerina2, D Herman1 & HI Pecina3


1Center for Clinical Neuroendocrinology and Pituitary Diseases;Department of Endocrinology, Diabetes and Metabolic Disaeses, University Hospital Sestre milosrdnice; University of Zagreb, Zagreb, Croatia; 2Department of Neurosurgery, University Hospital Sestre milosrdnice; University of Zagreb, Zagreb, Croatia; 3Department of Radiology, University Hospital Sestre milosrdnice; University of Zagreb, Zagreb, Croatia.


Over the 10 percentage of all intracranial tumors are pituitary tumors.

Their malignicity depends on their localisation, meanwhile their biological nature is benign. Regarding the size there are microadenomas (smaller than 10 milimeters) and macroadenomas (10 milimeters or more).

Clinical manifestations of pituitary tumors depend on their localisation and hormonal activity. They are either hormonally functional or nonfunctional, respectivelly.

In our Center for Clinical Neuroendocrinology and Pituitary Diseases, Clinical Hospital, there have been examined and treated 504 patients with pituitary tumors, in the last working 10 years. All patients were analised by tumor type: 182 patients with prolactinomas, 137 patients with acromegaly, 70 patients with Cushing’s disease and 115 patients with non- functional pituitary tumors. Patients came from the whole territory of our Republic. They were separated on the regional base: Mediterranean (coast) and continental region. The aim of our study was to see if the natural conditions and different life style (including food, water, or war events) have any impact on appearance of pituitary tumors. In Mediterranean region were found 127 patients with pituitary tumors. Mb Cushing had 19 (15%), prolactinoma 42 (34%), acromegaly 36 (28%), and nonfunctional tumors had 30 patients (23%). In continental region were found 377 patients (because of the largest number of inhabittants). Cushing had 51 patients (14%), prolactinoma had 140 (37%), acromegaly 101 (27%) and nonfunctional tumor had 85 patients (22%). Our results show there is no statisticaly significant difference among presentation between these two regions. The natural and life conditions have no impact on appearance of some types of tumors. The incidence of pituitary tumors is very similar to data we found in the literature.

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