Endocrine Abstracts (2005) 11 P463

An intrasellar germinoma with normal cerebrospinal fluid β-HCG concentration misdiagnosed as hypophysitis

Sinan Tanyolac1, Ayse Cikim2, Nese Ozbey1, Altay Sencer3, Ramaza Kurt3, Serra Sencer4, Inan Turantan3 & Senay Molvalilar1


1Istanbul University Istanbul Faculty of Medicine Departmant of Internal Medicine Division of Endocrinology and Metabolism, Istanbul, Turkey; 2Inonu University, Faculty of Medicine, Endocrinology and Metabolism, Malatya, Turkey; 3Istanbul University Istanbul Faculty of Medicine Departmant of Neurosurgery, Istanbul, Turkey; 4Istanbul University Istanbul Faculty of Medicine Departmant of Radiodiagnostic, Istanbul, Turkey.


Intracranial germinomas are malignant neoplasms which are supposed to arise from primitive germ cells failed to migrate to the genital crest during embryonic development. Most of them are located in the intra-suprasellar region and may cause anterior and particularly posterior pituitary hormone deficits. Early establishment of the histological diagnosis is important for optimum treatment planning and a successful outcome. Intracranial germinomas are radiosensitive and potentially curable. In this study we report a case of an intrasellar germinomas leading to infundibular thickening with lymphohistiocytic reaction and normal β-HCG concentrations in the cerebrospinal fluid (CSF).

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