35-year old female patient with bilateral pheochromocytoma and operated medullary carcinoma of thyroid gland (MEN II B sy.) is put in the octreotide therapy as she doesnt accept operation as a therapy because of religious reasons (transfusion of blood) and attacks of artery hypertension couldnt be control with alfa-adrenergic receptors antagonists.
12 MONTH 2004 ADRENALIN-urine 890 nmoldU/l (10.265.5); NORADRENALIN-urine >5000 nmoldU/l (32.5271.9); VMA >1000 mcmoldU/l (15.631.8); CALCITONIN 310 pg/ml (<13); CHROMOGRANIN A 1635 ng/ml (<60); NMR scan: right suprarenal gland 4×3 cm; left suprarenal gland 11×9 cm.
Artery pressure RR 200/150 mmHg.
09 MONTH 2005 ADRENALIN-urine 651 nmoldU/l (10.265.5); NORADRENALIN-urine 760 nmoldU/l (32.5271.9); VMA 410 mcmoldU/l (15.631.8); CALCITONIN 292 pg/ml (<13); CHROMOGRANIN A 1307 ng/ml (<60);
NMR scan: right suprarenal gland 4×2 cm; left suprarenal gland 11×7 cm.
Artery pressure RR 130/90 mmHg.
In comparation with test results from 12 month 2004 is evident decrease of chatecholamine, calcitonin and chromogranin A secretion with decrease size of bilateral adrenal tumors. Artery pressure is satisfactory regulated. The octreotide therapy is acceptably alternative to surgically treatment in cases where the operation is not possible.
01 - 05 Apr 2006
European Society of Endocrinology