Endocrine Abstracts (2006) 11 P646

Hormonal status of women with benign endometrial hyperplastic lesions

AA Osipova2, VA Matveeva1, AV Samoilova1 & AG Gunin1


1Department of Obstetrics and Gynecology Medical School Chuvash State University, Cheboksary, Russia; 2Department of Reproductive Medicine and Surgery, Moscow State Medico-Stomatological University, Moscow, Russia.


Retrospective randomized blinded study was carried out to find differences in hormone levels in blood between groups of patients with normal endometrium and with endometrial benign hyperplastic lesions. Hospital cases were randomly selected from journals of admittance from 1997 to 2005 years. Only patient name, age and clinical diagnosis, in which endometrial histology was reflected, could be viewed at the time of cases selection. There were to groups of cases selected, with and without of endometrial hyperplastic lesions. All patients included in the study had similar age, regular menstrual, suffered from primary or secondary infertility and was examined in the hospital by the standard infertility protocol. Their cases therefore contained data on endometrial histology, levels of LH, FSH, PRL, estradiol and progesterone in serum. There were 14 cases with proliferative endometrium and 37 cases with secretory endometrium in group with normal endometrium (51 cases in total). Group with endometrial hyperplastic lesions consisted of 26 cases with endometrial cyst hyperplasia, 2 cases with endometrial atypical hyperplasia and 27 cases with endometrial polyp (54 cases in total). Concentrations of LH, FSH and progesterone in serum were almost similar between the groups. It was surprising that patients with endometrial hyperplastic processes had lower estradiol level than that in women with normal endometrium (60.41±9.81 vs 80.62±12.75 pg/ml). Although this difference was not statistically significant (P>0.05). It was also amazing that prolactin level in serum of patients with hyperplastic endometrial pathology was significantly lower than that in patients with normal endometrium (400.71±44.04 vs 590.45±49.29 mIU/l; P<0.001). Thus, only one significant difference in levels of reproductive hormones was found between groups of women with and without endometrial hyperplastic lesions. This is lowered PRL level in women with endometrial hyperplastic processes.

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