The work presents results of examination of 60 obese fertile women (aged 31.1±2.35) with various reproductive disorders aiming at assessment of Siofor efficacy in restoration of endocrine and reproductive function. In the women BMI, type of constitution and waist/hip index (WHI) were measured, before and after 6- month therapy with Siofor glucose challenge test being performed and levels of LH, FSH, testosterone, PRL, cortisol, progesterone, estradiol insulin and C-peptide being measured. 10 women of the matched age with normal menstrual and reproductive function were included into the control group. Clinical efficacy of therapy was assessed by BMI and WHI dynamics, menstrual cycle restoration and pregnancy. Menstrual cycle ovulation capacity was confirmed by progesterone plasma level on 21st23rd day of the cycle and by folliculometry.
The examination showed long-term (7.3±2.3 years) menstrual cycle disorders in 35 women (58%), primary infertility with duration of 6.5±3.2 years being registered in 12 (20%), polycystic ovary syndrome in 13 (21.6%). All patients had obesity of various degrees; mean BMI being 35.0±3.3 kg/m2 and waist/hip circumference ratio 0.95±0.05. Concentrations of hormones were as follows: 10.25±2.5 MU/l of LH, 6.69±1.2 MU/l of FSH, 1.20 nmol/l of testosterone, 10.26 MU/l of PRL, 633.2±34.6 nmol/l of cortisol, 43.7±0.24 of progesterone and 203.09±12.5 of estradiol.
Results of glucose tolerance test show no confident difference of basal insulin (9.7±1.3) and glucose (4.0±0.9) from those in the control group (7.9±1.2 and 4.2±0.1, respectively). 2 -hour glucose values in the examinees and control were confidently different, but there was no confident difference in final values (5.1±1.7 and 4.5±0.4). Insulin in the examinees was significantly higher that in the control group (81.1±1.9 vs 11.6±0.9).
01 - 05 Apr 2006
European Society of Endocrinology