Polycystic Ovary Syndrome (PCOS) is the most common endocrine disorder in women of reproductive age often associated with insulin resistance, diabetes mellitus, hyperandrogenism, dislipidemia, obesity and hypertension, pathological conditions predisposing to high cardiovascular risk. Insulin resistant subjects may have higher plasma renin activity and it is well known that aldosterone plays a well-recognized role in the pathophysiology of hypertension and in the development of cardiovascular diseases. In order to evaluate this hypothesis, 25 young (23.8±1.3yr), over-weight/obese (31.5±1.5 Kg/m2) PCOS women and 16 healthy age- and body mass index (BMI)-matched controls were enrolled. Blood pressure, renin-angiotensin-system parameters (Plasma Renin Activity, PRA and plasma Aldosterone) and androgens profile were investigated in both groups after a seven days hyposodical-normocaloric diet. Insulin, glucose, and lipid profile were also evaluated and the Homeostasis Model Assessment of insulin Resistance Index (HOMA-IR) was calculated. Results obtained in PCOS women did not significantly differ from those obtained in controls concerning blood pressure (122.4±2.1/80.1±1.6 vs 123.1±4.7/84.4±4.0 mmHg), circulating renin-angiotensin-system (PRA: 3.7±0.5 vs 3.0±0.6 ng/ml/h; Plasma Aldosterone: 21.1±2.5 vs 27.9±5.3 ng/dl) and PRA/Aldosterone rate was 6.85 (nv<70). Our results indicate that young and over-weight/obese patients with PCOS, despite an adverse clinical assessment, show similar concentrations in renin and aldosterone plasma levels comparable to those of age- and BMI- matched controls, non positive correlations were found between HOMA, BMI and androgens plasma levels and renin, aldosterone and renin-aldosterone rate. These data suggest that these patients are not exposed to an early and higher cardiovascular risk, at least in young age.
01 - 05 Apr 2006
European Society of Endocrinology