Endocrine Abstracts (2006) 11 P795

Prevalence of amiodarone-induce thyroid disorders in iodine deficiency region

SI Ismailov, NL Kayumova & N Abdusalamova

Institute of Endocrinology of Ministry of Health, Tashkent, Uzbekistan.

Uzbekistan is area of low dietary iodide intake (45.5% of population with iodide deficiency) and high goiter prevalence (more then 40%).

Objective: The aim of this study was to investigate the prevalence of amiodarone-induce thyroid disorders among patients residence in iodine deficiency region.

Patients and methods: We observed 46 patients with supraventricular or ventricular arrhythmias, aged 53±12 years. The mean duration of treatment with amiodarone was 20 (3–36) months. Control group was consists 20 patients without thyroid diseases. The research program consisted physical examination, thyroid palpation, ultrasound, reflexometry, FNAB. TSH, fT3, fT4 was estimated by RIA method.

Results: Normal TSH and thyroid hormones were found in 33 (48.1%) of examined patients. Abnormal TSH, fT3, fT4 hormones values were seen in 13 patients. Hypothyroid patients had previously goitre. Mean age of this group was 44.6 years. Patients with Hyperthyroidism were consist 10 (21.7%) aged 38.0 years.

GroupTSH (mM/I)fT3 (nM/ml)fT4 (nM/ml)Mean age
Euthyroid (n=33)1.99±0.191.99±0.05123.6±3.5444.2
Hypothyroid (n=3)5.2±0.610.7±0.150±1.7354.6
Hyperthyroid (n=10)0.17±0.033.13±0.07199.2±9.9138.4

Conclusion: In iodine deficiency region more then 1 year amiodarone intake lead to development of amiodarone-associated thyroid dysfunction in 28.2% of patients (hypothyroidism and thyrotoxicosis in 6.5% and 21.7% respectively). Previously thyroid diseases predispose to amiodarone-induce hypothyroidism. Amiodarone-associated hypothyroidism increased in elderly.

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