Dyslipidemia is frequently registered in the patients with hypothyroidism (HLP type 2a, 2b, 4). Its atherosclerosis acceleration role is well known.
Objective: To evaluate lipids profile in newly diagnosed hypothyroidism and to assess atherosclerosis features by carotid scan morphological parametres.
Matherial and methods: Study involeved 30 newly diagnosed hypothyroid females (54±10 years). After the completion of lab (including lipids profile) and ultrasound thyroid evaluation, carotid Doppler scans were performed.
Results: Mean TSH level was 44.9±45.6 mIU/l. Positive thyroid antibody screening was observed in 16 patients, but 97% patients had typical ultrasound presentation of Hashimoto as well the same percentage of some HLP (18 patients HLP 2a). Clinically significant increase in RI (>75%) and intima-media thickness (≥1.1 mm) was registered in 3 and 15 patients respectively. We didnt find significant influence of hypothyroidism severity (TSH >30 mIU/l) and intima-media thickness on RI. Carotid branch stenosis (mean 38±5%) was confirmed in 6 patients. 83% patients with stenosis had HLP2a and all of them had significant intima-media thickness. No one of the patients had cerebrovascular or cardiovascular accident.
Conclusion: Nearly all evaluated patients had dyslipidemia. Incipient atherosclerotic carotid scan changes were registered in more than a half of patients. Despite high cardiovascular and cerebrovascular mortality rates in hypothyroid population, could decreased body metabolism, beside many factors, be protective in this way at the onset of disease?
01 - 05 Apr 2006
European Society of Endocrinology