Endocrine Abstracts (2006) 11 P840

Levothyroxine suppressive therapy in thyroid nodules

S Azzoug, K Maachi & F Chentli


Bab El Oued Hospital, Algiers, Algeria.


The efficacy of Levothyroxine suppressive therapy in thyroid nodules is still controversial; the aim of this study is to evaluate the effect of levothyroxine on nodule volume.

Subjects and methods: Ninety three euthyroid patients (92 females, mean age =43.7 years) harboring multindular (n=53) or solitary (n=40) nodules hare been treated for at least 6 months with thyroid hormones (Levothyroxine), the nodule size is assessed by it’s maximal diameter on sonography, a decrease of 20% or more is considered as significant.

Results: After a mean period of treatment of 18 months, 32% of the patients showed a significant decrease in nodule volme with a complete disappearance of the nodule in 11% despite an insufficient dosage as evidenced by thyrotropin which wasn’t well sppressed, the response rate is better in solitary nodules than in multinodular goiter.

Conclusion: We conclude from this study that hormonal suppressive therapy is an effective treatment at least in some patients in reducing nodule volume.

Article tools

My recent searches

No recent searches.

My recently viewed abstracts