Searchable abstracts of presentations at key conferences in endocrinology
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Society for Endocrinology BES

Symposia

Endocrinology of senescence

ea0013s17 | Endocrinology of senescence | SFEBES2007

The role of androgens in the ageing male

Matsumoto Alvin M

In men, aging is associated with a gradual and progressive decline in serum testosterone (T) levels, such that an increasing proportion of aging men have T levels below the normal range in young men, i.e. in the hypogonadal range. The age-related de-cline T levels is associated with alterations in body composition (decreasing lean and increasing fat mass), decreases in muscle mass and strength, bone mineral density (BMD), sexual function, and cognitive function, and depressed ...

ea0013s18 | Endocrinology of senescence | SFEBES2007

Estrogen receptors in development and ageing

Gustafsson Jan-aka , Fan Xiaotang , Kim Hyunjin , Warner Margaret

We have previously demonstrated that ERβ is necessary for embryonic development of the brain as early as E14.5 and is involved in neuronal migration. Such early effects of estrogen receptors were unexpected because estradiol synthesis and action in the brain are well documented to occur at E18.5.Since the presence of ERβ in the embryonic brain has not been demonstrated, it remained possible that the developmental abnormalities in ERβ−/− mi...

ea0013s20 | Endocrinology of senescence | SFEBES2007

Stress hormones, innate immunity and ageing

Lord Janet

As humans age their ability to combat bacterial infection declines and reduced immunity is further compromised at times of emotional and physical stress. Adrenocortical hormones are elevated in response to chronic stress in both young and old, but the quality of the response is dramatically altered with aging. The adrenal steroid dehydroepiandrosterone sulphate (DHEAS) is immune enhancing, while cortisol is immune suppressing. Serum DHEAS levels decline with age but cortisol d...