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9th European Congress of Endocrinology

Oral Communications

Endocrine tumors & neoplasia

ea0014oc3.1 | Endocrine tumors & neoplasia | ECE2007

Multiple somatostatin receptor subtypes activation reduces cell viability in non-functioning pituitary adenomas by inhibiting Vascular Endothelial Growth Factor secretion

Zatelli Maria Chiara , Piccin Daniela , Tagliati Federico , Ambrosio Maria Rosaria , Bianchi Antonio , Bondanelli Marta , Schmid Herbert A , Scanarini Massimo , Marinis Laura De , Maira Giulio , Uberti Ettore C degli

Somatostatin (SRIF) analogs have been employed in medical therapy of non-functioning pituitary adenomas (NFA), with contrasting results. Previous evidence showed that SRIF can exert its antiproliferative effects by reducing Vascular Endothelial Growth Factor (VEGF) secretion and action, and that VEGF expression may be related to pituitary tumor growth. The aim of our study was to clarify the possible effects of a multireceptor SRIF ligand on VEGF secretion and cell proliferati...

ea0014oc3.2 | Endocrine tumors & neoplasia | ECE2007

Adrenal lesions in multiple endocrine neoplasia type 1: data from the French Group for the Study of Endocrine Tumors (GTE)

Gatta Blandine , Monsaingeon Maud , Goudet Pierre , Murat Arnaud , Niccoli-Sire Patricia , Calender Alain , Rohmer Vincent , Chabre Olivier , Tabarin Antoine

The characteristics of adrenal involvement in Multiple Endocrine Neoplasia type 1 (MEN1) have been defined from studies involving a limited number of patients. We have assessed retrospectively the prevalence, characteristics and evolution of adrenal involvement from the French group for the study of endocrine tumours (GTE) registry, involving 688 patients with MEN1. In our series, adrenal tumours identified at abdominal imaging occurred in 130 patients (18.9%). The mean age of...

ea0014oc3.3 | Endocrine tumors & neoplasia | ECE2007

BMP dependent effects on adrenal tumorigenesis and function

Johnsen Inga , Kaufmann Sarah , Spady Lilia , Beuschlein Felix

Members of the TGFb family of ligands - including bone morphogenic proteins (BMPs) - have been demonstrated to profoundly impact tumorigenesis in a variety of tumor entities. As for the adrenal cortex, BMP6 has been implicated as an important modulator of aldosterone secretion. To screen for alterations of TGFß dependent pathways in adrenal tumorigenesis we performed gene profiling experiments. By comparing human adrenal carcinoma (ACC) against normal adrenal tissue sampl...

ea0014oc3.4 | Endocrine tumors & neoplasia | ECE2007

RET mutation – Tyr791Phe – the genetic cause of different diseases derived from neural crest

Vaclavikova Eliska , Dvorakova Sarka , Vlcek Petr , Skaba Richard , Bilek Radovan , Bendlova Bela

Familial medullary thyroid carcinoma (MTC), multiple endocrine neoplasia types 2A and 2B (MEN2A, 2B) and Hirschsprung disease (HSCR) are inherited neurocristopathies linked to germline mutations in the RET proto-oncogene. Activating germline RET mutations are presented in patients with FMTC, MEN2A and MEN2B, on the other hand, inactivating germline mutations in patients with HSCR. Nevertheless, there is an overlay in specific mutations in the exon 10 of the RET proto-oncogene....

ea0014oc3.5 | Endocrine tumors & neoplasia | ECE2007

[123I]Iodometomidate as a radiotracer for adrenal scintigraphy – first clinical experience

Hahner Stefanie , Stuermer Andrea , Fassnacht Martin , Kreissl Michael , Reiners Christoph , Beuschlein Felix , Zink Martina , Zolle Ilse , Schirbel Andreas , Allolio Bruno

Adrenal masses are highly prevalent tumours comprising of a variety of entities. Therefore, therapeutic consequences also vary considerably. The CYP11B-specific PET-tracer [11C]metomidate has been shown to be suitable to characterize adrenal lesions. However, its availability is restricted to PET-centers with an on-site cyclotron. Also imaging is hindered by the short tracer half-life (20 min). Therefore, we have developed [123I]iodometomidate as a tracer...

ea0014oc3.6 | Endocrine tumors & neoplasia | ECE2007

ERß-specific transcriptional profile in colon cancer

Martineti Valentina , Mascherini Massimiliano , Mavilia Carmelo , Sala Silvia Carbonell , Tognarini Isabella , Azzari Chiara , Stefanini Federico Mattia , Tonelli Francesco , Brandi Maria Luisa

Epidemiological data clearly evidence a protective role of estrogens against the development of colon cancer and ERβ has been identified as the predominant ER subtype in human colon. More recently it has been identified as a favourable prognostic marker in this disease, possibly explaining the protective effect of estrogens against colon cancer development. To understand the specific role and mechanism of action of ERβ in colon tumorigenesis we developed an in vit...

ea0014oc3.7 | Endocrine tumors & neoplasia | ECE2007

Fasting insulin levels are predictors of colonic lesions in patients with acromegaly: an observational, open, prospective study in 189 patients

Colao Annamaria , Pivonello Rosario , Galdiero Mariano , Auriemma Renata S. , Ferone Diego , Marzullo Paolo , Lombardi Gaetano

Elevated insulin levels are correlated with colonic adenomas and carcinomas in the general population. Patients with acromegaly are considered at high risk to develop colonic lesions and have a high insulin levels. To evaluate the role of insulin levels on colonic polyps (hyperplastic, adenomatous, single or synchronous) or adenocarcinoma in acromegaly we designed this analytical, observational, open, prospective, study enrolling 189 patients (100 women, 89 men, age 20–82...