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9th European Congress of Endocrinology

Oral Communications

Neuroendocriology basis

ea0014oc4.1 | Neuroendocriology basis | ECE2007

Organismal, cellular and molecular evolution of water balance regulation in vertebrates: the amphibian hinge

Acher Roger , Chauvet Jacqueline , Rouillé Yves

Amphibia, through metamophosis, recapitulate the evolution of water homeostasis from aquatic life to terrestrial one. Whereas the tadpole has the status of a freshwater fish, the adult has developed a three osmoregulatory organ system, including kidney, bladder and skin, for facing terrestrial dehydration. Amphibia have differentiated epithelial hydroosmotic cells in each organ: principal cells in nephron collecting duct, granular cells in urinary bladder, principal cells in v...

ea0014oc4.2 | Neuroendocriology basis | ECE2007

Growth Hormone-Releasing Hormone (GHRH) exerts protective effects on adult rat hippocampal progenitor cells

Destefanis Silvia , Johansson Inger , Aberg David , Granata Riccarda , Ghigo Ezio , Isgaard Jorgen

Growth hormone releasing hormone (GHRH) is a neuropeptide mainly synthesised in the hypothalamus, known to exert a stimulatory effect on the synthesis and release of growth hormone (GH) from the pituitary via the activation of specific receptors. New data indicate that GHRH is also produced in both extrahypothalamic brain areas and in peripheral tissues. GHRH-receptor splice variants (SVs) have been found in several peripheral normal and neoplastic human tissues and mediate ef...

ea0014oc4.3 | Neuroendocriology basis | ECE2007

Absence of germline AIP mutations in early onset sporadic somatotropinomas

Gomes Leonor , Prazeres Hugo , Paiva Isabel , Ribeiro Cristina , Rebelo Olinda , Martins Teresa , Lacerda Manuela , Carvalheiro Manuela

Objective: The pathogenesis of pituitary tumours is still incompletely understood. Somatotropinomas occur both sporadically and in the context of familial syndromes, such as multiple endocrine neoplasia type 1 (MEN1), Carney complex (CNC) and isolated familial somatotropinoma (IFS). Recently, germline mutations were reported in AIP (aryl hydrocarbon receptor interacting protein) gene in Finish and Italian families and in Finish patients with apparently sporadic pituitar...

ea0014oc4.4 | Neuroendocriology basis | ECE2007

Is there a role for dopamine D2 receptor gene polymorphisms in determining cabergoline sensitivity in prolactin-secreting pituitary adenomas?

Filopanti Marcello , Barbieri Anna Maria , Angioni Rita , Lania Andrea , Mantovani Giovanna , Spada Anna , Beck-Peccoz Paolo

Dopamine agonist cabergoline (CB) is the first-choice treatment in prolactin-secreting adenomas (PRL-omas). It is effective in reducing PRL secretion and tumour size in about 90% of patients by binding dopamine D2 receptor (DRD2). Although no mutations in DRD2 were found, it has been reported that several polymorphisms of this locus associate with alcoholism and schizophrenia, diseases in which dopaminergic system plays an important role. To assess the possible asso...

ea0014oc4.5 | Neuroendocriology basis | ECE2007

Lack of nuclear Hes1 expression coincides with transformation of endocrine pancreatic cells in Men1 knock out mice

Johansson Térèse , Lejonklou Margareta Halin , Skogseid Britt

Background: Homozygous inactivation of the MEN1 tumor suppressor gene frequently occurs in endocrine pancreatic tumors (EPT); however, a heterozygous germ line inactivation of the gene seems to lead to development of an increase amount of endocrine pancreatic cells. The Notch signaling cascade plays a vital role in sustaining the balance between cell proliferation, differentiation and apoptosis during pancreatic development. Whether Notch signaling is MEN1 depend...

ea0014oc4.6 | Neuroendocriology basis | ECE2007

Metabolic abnormalities in patients with adrenal adenomas may be associated with BclI polymorphism in the glucocorticoid receptor (GR) gene and expression of tumor-specific hsp70 isoforms

Damjanovic Svetozar , Antic Jadranka , Beleslin Bojana , Ognjanovic Sanja , Vignjevic Jovana , Petakov Milan , Macut Djuro , Paunovic Ivan , Isailovic Tatjana , Popovic Bojana , Bozic Ivana

Introduction: Intronic BclI polymorphism of glucocorticoid receptor (GR) gene and adrenal adenomas of incidental discovery are frequently associated with metabolic syndrome. We studied in these patients metabolic and hormonal parameters, the sequence alteration in BclI polymorphism of the GR gene from constitutive DNA and the expression of Hsp70 within the tumor and in tissue adjacently to tumor.Patients and methods: We assessed 114 healthy...

ea0014oc4.7 | Neuroendocriology basis | ECE2007

Function and evolution of GHRH, PACAP and PRP in vertebrates

Chow Billy KC , Siu Francis KY , Tam Janice KV , Lee Leo TO

In mammals, GHRH is the most important neuroendocrine factor that stimulates the release of GH from the anterior pituitary. In non-mammalian vertebrates, however, the previously named GHRH-like peptides were unable to demonstrate robust GH-releasing activities. In this report, we provide evidence that these GHRH-like peptides are homologues of mammalian PACAP-related peptides (PRP). Instead, GHRH peptides encoded in cDNAs isolated from goldfish, zebrafish and African clawed fr...