Endocrine Abstracts

The thyroid hormone receptors (TRs) are ligand-dependent transcription factors regulating growth, development, and differentiation. That TRs are cellular homologs of the retroviral v-erbA oncogene suggests their possible involvement in carcinogenesis. Recent studies showed altered expression of TRs at both the mRNA and protein levels and identified somatic mutations of TRs in several human cancers, including thyroid carcinomas. We have created a knockin mutant mouse by targeti...

Sheue-yann Cheng, Gene Regulation Section, National Institutes fo Health, Bethesda, MD, USA AbstractSheue-yann Cheng, PhD, is the chief of the Gene Regulation Section, Laboratory of Molecular Biology, National Cancer Institute (NCI), National Institutes of Health (NIH) and an advisor for women scientists at the Center for Cancer Research, NCI. She is on the editorial boards of Thyroid, Endocrinology, and Expert Revi...