Searchable abstracts of presentations at key conferences in endocrinology
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10th European Congress of Endocrinology

Symposia

Thyroid cell biology

ea0016s17.1 | Thyroid cell biology | ECE2008

Basic mechanisms of thyroid development

Zannini Stella

Tissue-specific transcriptional regulation is achieved by the combined action of transcription factors, co-regulators and components of the basal transcriptional machinery. The goal of our work is to unravel the mechanisms involved in the regulation of the activity of thyroid-specific transcription factors. We have demonstrated that the transcription factor Pax8 is required for the expression of all the thyroid-specific genes that are considered markers of the differentiated p...

ea0016s17.2 | Thyroid cell biology | ECE2008

Growth factors involved in thyroid cells differentiation

Santisteban Pilar

Cell differentiation occurs as a result of the concerted activation of multiple signalling pathways in response to environmental stimuli. We have stu died the role elicited by several growth factors and oncogenes in the control of Sodium/Iodide Symporter (NIS) gene expression, a thyroid differentiation marker. Our results have shown that IGF1/PI3K and TGFbeta/Smads inhibit NIS gene transcription induced by TSH/cAMP, a mechanism mediated by the inhibition of Pax8 binding to NIS...

ea0016s17.3 | Thyroid cell biology | ECE2008

Molecular mechanisms of thyroid carcinogenesis: role of the CBX7 gene: Loss of the CBX7 gene.ll

Pallante Pierlorenzo , Federico Antonella , Bianco Mimma , Ferraro Angelo , Troncone Giancarlo , Fusco Alfredo

Using gene expression profiling we found that the CBX7 gene was drastically down-regulated in six thyroid carcinoma cell lines versus control cells. This suggested that CBX7 is an oncosuppressor. The aim of this study was to determine whether CBX7 is related to thyroid cancer phenotype, and to try to identify new tools for the diagnosis and prognosis of thyroid cancer. We thus evaluated CBX7 expression in various snap-frozen and paraffin-embedded thyroid carcinoma tissues of d...

ea0016s17.4 | Thyroid cell biology | ECE2008

Novel insights on the Na+/I symporter (NIS): it mediates electroneutral active transport of the environmental pollutant perchlorate

Dohan O , Portulano C , Basquin C , Paroder M , Nicola JP , Maestas MJ , Eskandari S , Reyna-Neyra A , Amzel LM , Carrasco N

The Na+/I− symporter (NIS) is a key plasma membrane protein that mediates active I− uptake in the thyroid, lactating breast, and other tissues with an electrogenic stoichiometry of 2 Na+ per I−. In the thyroid, NIS-mediated I− uptake is the first step in the biosynthesis of the iodine-containing thyroid hormones, which are essential early in life for proper development of the central nerv...