Endocrine Abstracts

Dysfunctional mitochondrial oxidative phosphorylation and diminished aerobic capacity are associated with metabolic, cardiovascular and neurodegenerative diseases that eventually alter life span. We will discuss two distinct signalling pathways to control energy expenditure that converge on the coactivator PGC-1α. In a first study we focussed on the polyphenol resveratrol, an activator of the class III HDAC SIRT1, the mammalian Sir2 homolog. Resveratrol significantly incr...