Endocrine Abstracts

The action of the regulatory neuropeptides vasoactive intestinal polypeptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) carries out through the shared receptors VPAC1 and VPAC2 and the exclusive PACAP receptor PAC1, all of which are G protein-coupled receptors. Formerly, we showed that the administration of both peptides enhance catecholamine, corticosterone and aldosterone release from adrenal cell co-culture. Further...

Background and aims: CXC chemokine ligand 10 (CXCL10) also known as chemokine interferon γ inducible protein (IP-10) is a CXCR3 chemokine belongs to a group of structurally related molecules, that induce the chemotaxis of diverse leukocyte subtypes including activated T-helper 1 lymphocytes, natural killer cells and monocytes. In patients with Hashimoto’s thyroiditis, type 1 diabetes mellitus and Graves’ disease high levels of CXCL10 ligand in serum have been fo...

Background: The prevalence of TS and other GID, as well as men/women ratio (MWR) of the pathology is the topic of a high interest for professionals in this field. The earlier data from Russia reported the MWR as 1:3 and were different from reported by other countries.Objective: To study the current prevalence of TS and other GID in Russia.Materials and methods: We summarized the data collected in 2006 by four Moscow clinics, experi...

More than twenty years after Chernobyl nuclear power plant explosion, radionuclides are still mainly bound to the organic soil layers. Currently, the radiation exposure is dominated by the internal exposure to gamma-radiation following the decay of 137Cs, due to presence of 137Cs into the food chain. Because of this persistence of contamination with 137Cs, questions regarding public health for people living in contaminated areas were raised. Se...

Uranium is the heaviest naturally occurring element found in the Earth’s crust. It is an alpha-emitter radioactive element that present both radiotoxicant and chemotoxicant properties. Uranium is present in environment as a result of natural deposits and releases by human applications (mill tailings, nuclear industry and military army). Populations could thus be exposed to uranium either through their drinking water or the food chain.Natural uranium...

Captive breeding of wild animals is a first step of domestication. The process is accompanied by a number of adaptations to captive conditions, which resulting in behaviour, physiological and morphological changes. One of morphological consequences of domestication is a coat-colour mutation named Star (S) that is characterised by some unpigmented areas on the skin. The dominant mutation was first revealed in farm-bred populations of silver foxes, but the highest frequency of t...

Serum levels of soluble RAGE (sRAGE total), the soluble isoform of the receptor of advanced glycated end products (AGEs) that lacks the transmembrane and intracytoplasmic domains of RAGE, has been found elevated in type 2 diabetics and non diabetic subjects and positively correlated with AGEs levels. In women with PCOS, while serum AGEs have been demonstrated to be elevated, sRAGE levels have not been determined as yet.The aim of the present study was to...

In female rats, diet enriched in advanced glycation end products (AGEs) has been associated with increased serum testosterone levels and deposition of dietary glycotoxins in ovarian tissue.Women with PCOS present increased serum AGE levels, which are acutely elevated after intake of a single meal high in AGE content. In this study the effects of a hypocaloric diet and an AGE-enriched hypocaloric diet were investigated, on the endocrine and metabolic prof...