Endocrine Abstracts

Objective: The present study designed to assess the effect of Mg+Zn, vitamin C+E, and combination of these micronutrients on glycemic control, lipid profile and lipid peroxidation in type 2 diabetic patients.

Materials and methods: In a randomized, double-blind, placebo controlled clinical trial, 69 type 2 diabetic patients were randomly divided into four groups, each group receiving one of the following daily supplement for 3 months; group M: 200 mg magnesium and 30 mg zinc (n=16), group V: 200 mg vitamin C and 150 mg vitamin E (n=18), group MV: minerals plus vitamins (n=17), group P: placebo (n=18).

Results: Results indicate that after 3 months of supplementation mean serum levels of HDL-C and apolipoprotein A1 increased significantly in the MV group by 24% (50.4±19.3 vs 40.6±10.8 mg/dl) and 9% (170±34 vs 156±24 mg/dl), respectively (P<0.01). Levels of fasting serum glucose decreased in MV group (P<0.05). Malondialdehyde concentrations decreased significantly in the M and MV groups (P<0.05 and P<0.01, respectively). Arylesterase activity increased significantly in the M group (91±24 vs 87±24, P<0.05) There were no significant changes in the levels of these parameters in the other groups. HbA1, fructosamine, insulin and HOMA score and serum levels of total cholesterol, LDL-C, triglyceride, apolipoprotein B and paraoxonase activities were not altered after supplementation in all 4 groups.

Conclusion: It is concluded that since co-supplementation of Mg, Zn, vitamin C and E significantly increases HDL-C and apolipoprotein A1 and improves fasting serum glucose and lipid proxidation, supplementation of these micronutrients should be recommended for the type 2 diabetic patients based on their daily requirements.