Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2008) 16 P24

ECE2008 Poster Presentations Adrenal (61 abstracts)

Association of diabetes mellitus and arterial hypertension in adrenal incidentaloma

Milos Zarkovic , Jasmina Ciric , Biljana Beleslin , Slavica Savic , Mirjana Stojkovic , Djordje Marina & Bozo Trbojevic


Institute of Endocrinology, Belgrade, Serbia.


Background/objectives: The aim of the study was to assess association between diabetes mellitus (DM) and arterial hypertension (AH) in patients with adrenal incidentaloma.

Design and methods: One hundred and eleven consecutive patients with incidentally discovered adrenal tumours were included in the study. OGTT was done and 24 h urinary catecholamines were measured. Aldosterone and plasma renine activity (PRA) were determined, and 1 mg dexametasone test was performed. Insulin sensitivity (Si) was calculated using BIGTT test. Data are presented as mean±S.D.

Results: In our study group, there was significant association between DM and AH. Out of 13 DM subjects, 12 were also hypertensive. Out of 98 non-diabetic subjects 38 were normotensive and 60 hypertensive (Fisher exact test P=0.031). As there was only one normotensive diabetic patient two-way analysis was not feasible. Subjects with diabetes mellitus had significantly lower Si (7.32±3.05 vs 3.58±0.84×10−5 (min×pmol)−1, P=0.21) and higher cortisol after 1 mg dexametasone (86.7±90.4 vs 155.0±192.5 nmol/l, P=0.05). Subjects with arterial hypertension were older (57.6±8.6 vs 52.7±9.9 years) and had significantly lower PRA (1.84±1.59 vs 3.85±3.52 ng/ml per h) compared to normotensive subjects.

Conclusions: In adrenal incidentaloma subjects significant association exists between DM and AH, probably caused by subclinical form of the Cushing’s syndrome.

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