Endocrine Abstracts (2008) 16 P222

Atherosclerotic factors, low antioxidant defense and cardiovascular diseases in retinal occlusions and anterior ischemic optic neuropathy

Branko Sreckovic1, Vesna Dimitrijevic-Sreckovic2, Natalija Kosanovic-Jakovic3, Predrag Djordjevic2, Emina Colak4, Fadil Canovic2, Svetislav Milenkovic3, Jecka Stojanovic2 & Mirko Resan3

1Institute of Cardiovascular Diseases, Clinical Center of Serbia, Belgrade, Serbia; 2Institute of Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Belgrade, Serbia; 3Institute of Ophtalmology, Clinical Center of Serbia, Belgrade, Serbia; 4Institute of Medical Biochemistry, Clinical Center of Serbia, Belgrade, Serbia.

Aim: The aim of the study was to examine the existence of cardiovascular diseases (CVD), atherosclerotic factors and antioxidant defense in patients with central retinal artery and central retinal vein occlusions (CRAO, CRVO) and anterior ischemic optic neuropathy (AION).

Materials and Methods: The study included 38 obese individuals with CRAO, CRVO and AION. Glycoregulation disorders were determined by OGTT. Lipid status was determined by spectrophotometry. Serum CRP was measured by immunometric assay. Microalbuminuria was determined by nephelometry. Activities of markers of antioxidant defense, superoxide dismutase (SOD) and glutation peroxidase (GSH-Px) were determined in erythrocytes.

Results: Disorder percentages in observed patients were as follows: CRAO 46.4%, CRVO 35.7%, AION 17.9%. CRAO, CRVO and AION patients had the following respective values of the following disorders: hypertension 63.3%, 60.0%; 80.0%; obesity 69.2%, 70.0%, 60.0%; hyperlipoproteinemia 84.6%, 100.0%, 80.0%; metabolic syndrome (MS) 69.2%, 70.0%, 80.0%; angina pectoris 30.8%, 10.0%, 40.0%; miocardial infarction 0%, 10%, 40%; impaired fasting glucose (IFG) 30.8%, 10.0%, 20.0%; diabetes mellitus type 2 (T2DM) 15.4%, 40.0%, 60.0%. LDL/HDL ratio was 3.3±1.4, 3.3±0.7 and 3.0±0.7. Lp(a) was 0.37±0.77, 0.43±0.38 and 0.13±0.1. Microalbuminuria was 21.7±14.7, 112.9±166.9 and 13.0±4.8. CRP was highest (P<0.01) in CRAO patients (3.7±1.4; 1.9±1.0; 0.9±0.7 mg/l). Decreased antioxidant defense was present in all disorders.

Conclusions: Visceral obesity, hypertension, hyperlipoproteinemia are associated with accelerated atherosclerosis and CVD, which was most frequent in CRAO (highest CRP as inflammatory factor, highest atherogenic risk factor LDL/HDL, high Lp(a)) and AION patients (most frequent T2DM with poor glycoregulation and MS with all its characteristics). Low antioxidant defense is associated with atherosclerosis and various vascular complications.