Endocrine Abstracts (2008) 16 P24

Association of diabetes mellitus and arterial hypertension in adrenal incidentaloma

Milos Zarkovic, Jasmina Ciric, Biljana Beleslin, Slavica Savic, Mirjana Stojkovic, Djordje Marina & Bozo Trbojevic

Institute of Endocrinology, Belgrade, Serbia.

Background/objectives: The aim of the study was to assess association between diabetes mellitus (DM) and arterial hypertension (AH) in patients with adrenal incidentaloma.

Design and methods: One hundred and eleven consecutive patients with incidentally discovered adrenal tumours were included in the study. OGTT was done and 24 h urinary catecholamines were measured. Aldosterone and plasma renine activity (PRA) were determined, and 1 mg dexametasone test was performed. Insulin sensitivity (Si) was calculated using BIGTT test. Data are presented as mean±S.D.

Results: In our study group, there was significant association between DM and AH. Out of 13 DM subjects, 12 were also hypertensive. Out of 98 non-diabetic subjects 38 were normotensive and 60 hypertensive (Fisher exact test P=0.031). As there was only one normotensive diabetic patient two-way analysis was not feasible. Subjects with diabetes mellitus had significantly lower Si (7.32±3.05 vs 3.58±0.84×10−5 (min×pmol)−1, P=0.21) and higher cortisol after 1 mg dexametasone (86.7±90.4 vs 155.0±192.5 nmol/l, P=0.05). Subjects with arterial hypertension were older (57.6±8.6 vs 52.7±9.9 years) and had significantly lower PRA (1.84±1.59 vs 3.85±3.52 ng/ml per h) compared to normotensive subjects.

Conclusions: In adrenal incidentaloma subjects significant association exists between DM and AH, probably caused by subclinical form of the Cushing’s syndrome.

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