Endocrine Abstracts (2008) 16 P243

Gestational diabetes has no additional effect on plasma thrombin-activatable fibrinolysis inhibitor antigen levels beyond pregnancy

Baris Akinci, Tevfik Demir, Saba Saygili, Serkan Yener, Inci Alacacioglu, Fatih Saygili, Firat Bayraktar & Sena Yesil


Dokuz Eylul University, Izmir, Turkey.


Pregnancy is a prothrombotic condition with increased levels of several circulating coagulation factors. The aim of the present study is to investigate the effect of gestational diabetes on plasma thrombin-activatable fibrinolysis inhibitor (TAFI) antigen levels.

Plasma TAFI and PAI-1 antigen levels were measured in 26 pregnant women with gestational diabetes, 25 pregnant women with normal glucose tolerance, and age matched 24 non-pregnant women with no history of gestational diabetes.

Increased plasma TAFI antigen levels were found in pregnant women compared to non-pregnant controls. However, no statistically significant difference in TAFI antigen levels was observed between women with gestational diabetes and pregnant controls. Plasma PAI-1 antigen levels were higher in gestational diabetes than pregnant and non-pregnant controls.

We suggest that pregnancy is associated with enhanced coagulation and impaired fibrinolysis. Despite increased PAI-1 antigen levels associated with gestational diabetes, the effect of gestational diabetes on TAFI antigen levels is lacking.

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