Endocrine Abstracts

Recent large twin studies have definitively shown that more than 70% of the variance of the BMI and waist is genetically determined in both adults and children, suggesting that the epidemics of obesity and subsequent T2D are mainly due to the environmental pressure targeting individuals who are particularly vulnerable to metabolic diseases. The dissection of monogenic early onset severe obesity and T2D cases have identified a variety of causative genes that are involved in two...