Endocrine Abstracts

Insulin-like growth factors (IGFs) play an important role in the pathogenesis of several neoplasias and the IGF-binding proteins (IGFBPs) may have a role as autocrine/paracrine factors in regulating the local actions of the IGFs. In the present study we investigated IGF-I, IGF-II, IGFBP-1, IGFBP-2, and IGFBP-3 production in cultured media from three human lung cancer cell lines (Calu-3, Calu-6, A549) and in human neoplastic and normal lung tissue samples obtained at surgery fr...

Mice overexpressing growth hormone (GH) have about two-fold higher IGF-I and clear increases in body and organ weights. Moreover, administration of GH to hypophysectomised or dwarf mice has been shown to increase IGF-I. Data on the short term effects of exogenous administration of rhGH in normal rodents remain scarce.Therefore, we measured IGF-I before and after one week of GH-treatment in 10-week-old female mice, injected daily with two different doses ...

The aim of the study was investigating of microvessels density (MD) and expression of vascular endothelial growth factor (VEGF) in adrenocortical tumors.Under investigation there were 23 adrenocortical tumors: adenomas – 13, ‘border’ tumors – 4, and carcinomas – 6. Immunohistochemical studied were carried out using monoclonal antibodies to both VEGF and endothelial marker CD34 (Dako). VEGF expression was estimated as a weak one (...

Plant growth factors are used commonly in agriculture. The effect of these factors on human health is unknown. Gibberellins are the most commonly used growth factors that have the structure of Diterpenoid acid. One of the gibberellins (GA3) induces tumor formation in mice but the mechanism of action is not known. We here examined changes in levels of GH and IGF-1 and examined whether there is a correlation between growth factors’ levels and weight changes.<p class="ab...