Endocrine Abstracts (2009) 20 P191

Clinical features and outcome of thyroid lymphoma: the Auvergne registry

Beatrice Roche1, Caroline Solmon1, Elena Robu1,2, Francoise Desbiez1, Philippe Thieblot1,2 & Igor Tauveron1,2


1CHU Endocrinology, Clermont Ferrand, France; 2UFR Medecine Université d’Auvergne, Clermont Ferrand, France.


Introduction: Thyroid lymphoma is a rare thyroid disease, occurring mostly in the elderly. We report a series of 13 cases from a single centre.

Material and methods: Among our regional registry (1294 cases of thyroid cancer), we report 16 cases of thyroid lymphoma (with sufficient data on follow up for 13).

Results: Mean age was 68.3 years (range 38–85) and included 12 women for 1 man. Nine patients also presented with Hashimoto’s thyroiditis. All but three were euthyroid. A cervical rapidly growing mass was the major revealing symptom (10/13).

Diffuse giant cell B lymphoma (D G C B L) was more common (10/13) with anti CD 19+, CD20+ and CD30− immunostaining. One patient had DGBCL issued from mucosa associated lymphoid tissue (MALT) and two ad Burkitt lymphoma (BL).

Follow up after appropriate therapy, ie conjunction according to staging of chemotherapy, radiotherapy or surgery, lead to remission in BL and MALT lymphoma, and in 3/10 DGBCL. The survival rate was 78.5 and 48.5% at 5 and 10 years respectively.

Conclusion: Thyroid lymphoma is a rare thyroid disorder, traditionally linked with Hashimoto’s thyroiditis. Prognosis of lymphoma is far better than anaplastic carcinoma which it may mimic. Yet the most frequent form, DGCBL, keeps a poorer prognosis than BL or MALT lymphoma.

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