Endocrine Abstracts (2009) 20 P314

Schmidt's syndrome atypical case

Larisa Dzeranova & Olga Gerasimenko


National Research Centre for Endocrinology, Moscow, Russian Federation.


Thyroid pathology, as a part of Schmidt’s syndrome, could be presented as a chronic autoimmune thyroiditis (95–97%) or as a Grave’s disease (3–5%). Usually refractory hypothyroidism develops after a chronic autoimmune thyroiditis occurs, so the permanent thyroid hormone replacement is necessary during all life. But we are investigating a different course of that disease.

A 31-year-old woman had been sick from 2003, when Schmidt’s syndrome was diagnosed by typical clinical and laboratory symptoms. Thyroid pathology was presented as a hypothyroidism after autoimmune thyroiditis, so a replacement therapy by thyroid hormones, mineralocorticoids, corticosteroids was administered. After hormones administration her general condition improved quickly and had been good until 2007; laboratory data demonstrated compensation of thyroid and adrenal insufficiency. In 2007, the patient appeared with weight loss, weakness, severe tachycardia, anxiety. Laboratory data revealed that a thyroid-stimulating hormone (TSH) serum level decreased below 0.01 mIU/l, free thyroxin – elevated to 58.8 pmol/l. L-thyroxin dose was reduced, but symptoms of thyrotoxicosis remained. After that a thyreostatic therapy with thyrozol administration was provided. The patient’s condition and laboratory data were controlled each three months, so the therapy type – thyrozol or L-thyroxin, or combination – was changed according to the investigation results. In June 2008, it was decided to cancel the whole thyroid therapy, after that and until recent time the patient felt good, and the laboratory investigation during this period demonstrated euthyroidism.

It’s well known that a similar disease course of thyroid pathology could occur in case of an isolated autoimmune thyroiditis, but we did not find such a clinical case description as a part of Schmidt’s syndrome in literature. Thyrotoxicosis combined with the adrenal insufficiency becomes a more dangerous condition than when alone, so in Schmidt’s syndrome case that condition should be diagnosed and treated in early stages.

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