Endocrine Abstracts (2009) 20 P417

Evaluation of the severity of hepatic steatosis in type 2 diabetes

Leila Ben Salem Hachmi1, Leila Ben Farhat2, Ridha Waghlani1, Chiraz Bouzid1, Lotfi Hendaoui2 & Claude Ben Slama1

1National Institute of Nutrition, Tunis, Tunisia; 2Mongi Slim Hospital, Marsa, Tunis, Tunisia.

Objective: The objective of this study was to examine the factors influencing the severity of hepatic steatosis in type 2 diabetes.

Methods: Computed tomography imaging was used to assess hepatic fat content in 80 men and women with type 2 diabetes. Inclusion criteria included a confirmed diagnosis of type 2 diabetes (≥1 year of duration), without history of hepatic disease or daily consumption of alcohol drink. The ratio of liver to spleen attenuation (L/S ratio) was calculated. Patients with an L/S ratio ≤ 0.8 were considered to have severe fatty liver. We compared the 2 groups with moderate and severe steatosis.

Results: The prevalence of hepatic steatosis was 30% (24/80). Steatosis was severe in 29% (7/24) and moderate in 71% of patients. Mean alanine aminotransferase level and C reactive protein level are significantly higher in diabetes with severe steatosis (respectively 25.8±5.3 vs 20.4±6 P=0.04–12.6±15.1 vs 4.7±2.7 P=0.04). No significant difference was found concerning age, duration of diabetes, anthropometric parameters, HbA1C, triglycerides level, HDL cholesterol level and total cholesterol level between the 2 groups.

Conclusions: Type 2 diabetic patient with higher liver enzyme especially alanine aminotransferase and positive inflammatory parameters had a higher risk of severe steatosis.

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