Endocrine Abstracts (2009) 20 P480

Serum adiponectin levels and polymorphism of CB1 endocannabinoid receptor (A3813G, A4895G, G1422A) in postmenopausal women

Diana Jedrzejuk1, Felicja Lwow2, Katarzyna Dunajska2, Lukasz Laczmanski1 & Andrzej Milewicz1

1Wroclaw University of Medicine, Wroclaw, Poland; 2University School of Physical Education, Wroclaw, Poland.

Recently, low serum adiponectin levels is created as a new risk factor for cardiovascular diseases in climacteric women. Our previous study shows that smoking, serum testosterone levels, blood pressure and BMI have the influence on serum adiponectin levels. Endocannabinoid system plays a role in regulation of food intake and fat accumulation, as well as lipid and carbohydrate metabolism. Menopause transition is related to metabolic disorders (e.g. obesity) and cause the increased risk of cardiovascular diseases. From randomly selected 6000 postmenopausal women, according to the protocol, we selected 360 women (aged 50–65) and finally 348 women was developed according to relation between the endocannabinoid receptor polymorphism and serum adiponectin levels. Standard method was used for DNA genomic isolation from lymphocyte. The polymorphism of endocannabinoid receptor was estimated using minisequenced technique. We have estimated BMI, waist circumference, % fat, gynoid and android fat deposit (using DXA method), blood pressure as well as lipid and carbohydrate metabolism and serum adiponectin levels (using RIA method) in polymorphism A3813G, A4895G, G1422A of CN1 gene. In our study we have found no significant influence of gene polymorphism on serum adiponectin levels, but in G/G genotype (polymorphism A3813G) we have found statistically significant higher BMI, % fat and android fat deposit in comparison to A/A genotype.

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