The authors studied the effect of one year of therapy with rhGH on growth velocity in patients with growth hormone deficiency (GHD). We analyzed 120 patients (85 boys and 35 girls), 621.5 years of age (mean 14.2±3.0) treated in Department of Endocrinology and Diabetology for Children and Adolescents, Medical University of Wrocław. Patients received rhGH in a dose of 0.7IU/Kg/week. Partial GHD was diagnosed in 71 cases (52 boys and 19 girls), complete GHD was diagnosed in 49 patients (34 boys and 15 girls). The therapy was started at 11.7±2.9 years. The mean height velocity in the first year of treatment was 8.72±2.27 cm per year; 8.77±1.76 cm per year in girls and 8.58±2.27 in boys. The mean height velocity in patients with complete GHD was pretreatment height was 8.94±2.56 cm per year; 8.85±1.63 cm per year in girls and 8.51±2.20 per year in boys. The mean height velocity in patients with partial GHD was 8.52±2.07 cm per year; 8.70±1.85 cm per year in girls and 8.62±2.27 per year in boys.
The present study shows that there is no statistically significant difference between studied groups.
25 - 29 Apr 2009
European Society of Endocrinology