Endocrine Abstracts (2009) 20 P530

The goiter etiology in children of the south west of Romania

Marginean Otilia1, Simedrea Ioan1, Lesovici Marilena1 & Crista Corina2


1Ist Pediatric Clinic, ‘Louis Turcanu’ Children Hospital, Timisoara, Romania; 2Endocrinology Department, Country Hospital, Timisoara, Romania.


Aim: To study the etiology and the treatment of the non endemic goiter, in our region.

Material and methods: The study group consisted of 67 children (F/M: 48/19; age: 4–17 years old) with non endemic goiter admitted in our hospital during the period, 2003–2008. The diagnostic procedures were represented by: the clinical examination (including the anthropometric measures and pubertal stages after Tanner’s criteria), laboratory data (serum cholesterol, triglycerides, urinary iodine), the thyroid function tests (TSH, freeT4, free T3), immunologic parameters (antiTPO and antithyroglobulin antibodies); thyroid ultrasonography (thyroid volume and aspect). The bone age and thyroid MRI were performed in selected cases. All the cases were followed over 36 month under treatment.

Results and discussions: According to the thyroid functional tests, the patients were divided in four groups. Group I: 28 euthyroid patients were treated with iodine and after 1 year the goiter disappeared in 25 patients (89.25%). Group II: 22 hypothyroid patients, (20 with chronic autoimmune thyroiditis (CAT) and 2 cases of dishormonogenesis). All the cases were treated with L-Thyroxin. The goiter decreased after 1 year, especially in the CAT cases. Group III: 9 patients with elevated serum TSH level (subclinical hypothiroism); only the children with high levels of the serum cholesterol were treated with L-Thyroxin. Group IV: 4 cases with autoimmune hyperthyroidism were treated, initially, with thiamazol and, subsequently, the children developed hypothyroidism and were treated, with L-Thyroxin.

Conclusions: 1. The goiter in childhood may have variable causes;In our region head especialy an autoimmune etiology.

2. The treatment depends on the etiology and thyroid function.

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