Endocrine Abstracts

Monogenic obesity disorders and mouse models of obesity have overwhelmingly pointed to hyperphagia as the predominant genetic force in promoting obesity, it was therefore no surprise when the most robust common variant associated with obesity from GWAS studies was associated with increased energy intake. We and other groups have shown that variants in the FTO gene are not associated with increased food intake per se, but rather display a preference for energy dense foods resul...

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The central serotonin (5-hydroxytryptamine, 5-HT) system is an established modulator of energy balance. Therefore, it is unsurprising that former (e.g. D-fenfluramine), current (e.g. sibutramine), and drug discovery (e.g. lorcaserin) obesity treatments target serotonin pathways to affect food intake and body weight. Pharmacological and genetic research implicates the Gq-coupled serotonin 2C receptor (5-HT2CR) and the Gi-coupled serotonin 1B receptor (5-HT1BR) sp...