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12th European Congress of Endocrinology

Plenary Lectures

Thyronamines: beyond T<subscript>4</subscript> and T<subscript>3</subscript>

ea0022pl4 | Thyronamines: beyond T<subscript>4</subscript> and T<subscript>3</subscript> | ECE2010

Thyronamines: beyond T4 and T3

Scanlan Thomas

In 2004, we reported the discovery of a new signaling molecule chemically related to thyroid hormones called 3-iodothyronamine (T1AM). T1AM is formally a decarboxylated and deiodinated derivative of thyroxine (T4) and was detected in tissues and circulation of rodents. Single-dose administration of T1AM to mice resulted in unique biological activities including hypothermia, bradycardia, and hyperglycemia. The T1AM-induced ...