Searchable abstracts of presentations at key conferences in endocrinology
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12th European Congress of Endocrinology

Poster Presentations


ea0022p67 | Bone/Calcium | ECE2010

Estimation of ionized calcium levels after thyroidectomy at King Abdul Aziz University Hospital (Jeddah)

Qari Faiza

Aim: To determine the incidence of hypocalcaemia and the need for calcium supplementation after thyroid surgery in 120 patients.Methods: A prospective study to determine the incidence of hypocalcaemia by measuring ionized calcium level in 120 patients underwent thyroidectomy at King Abdul Aziz University Hospital, the data included pre- and post-operative ionized calcium level, albumin, free thyroxine, thyrotopin and alkaline phosphatase. As well include...

ea0022p68 | Bone/Calcium | ECE2010

Imatinib mesylate disturbs bone growth and remodellation in postnatal rats

Nurmio Mirja , Joki Henna , Kallio Jenny , Maatta Jorma , Vaananen Kalervo , Toppari Jorma , Jahnukainen Kirsi , Laitala-Leinonen Tiina

Imatinib mesylate is a well-tolerated receptor tyrosine kinase inhibitor that has gained interest as a potential treatment for osteoporosis and other metabolic bone diseases. It is clinically approved for the treatment of chronic myelogenous leukaemia (CML), Philadelphia-positive acute lymphoblastic leukaemia and gastrointestinal stromal tumors (GIST), and targets the receptors for PDGFs, ABL-related gene, c-Abl, c-Kit and c-Fms. Altered bone and mineral metabolism has been de...

ea0022p69 | Bone/Calcium | ECE2010

Parathyroid hormone levels in hemodialysis patients

Passalidou Ioanna , Karapavlidou Paraskevi

Introduction: Parathyroid hormone (PTH) starts to rise very early in the course of kidney disease. As kidney disease progresses, plasma levels of vitamin D and calcium begin to decline, thus contributing to greater secretion of PTH. In addition, the retention of phosphate further increases PTH secretion independent of calcium and vitamin D levels. Continued stimulation of PTH secretion leads to irreversible parathyroid gland hyperplasia.Objectives: To me...

ea0022p70 | Bone/Calcium | ECE2010

Bone mineral density in Ukrainian women of different age with thyrotoxicosis

Povoroznyuk Vladyslav , Oliynyk Olexandr

Thyrotoxicosis has been linked to osteoporosis and increased fracture risk. On the other hand, decreasing serum levels of estrogens in postmenopausal women potentially may increase effect of thyroid hormones on bone tissue. Dual-energy X-ray absorptiometry is an accurate and precise method of determining BMD, and has been wildly-used for diagnosing osteopenia and osteoporosis. The aim of our study was to study by means of DXA the peculiarities of bone loss in women of differen...

ea0022p71 | Bone/Calcium | ECE2010

Relationship of serum leptin and bone mineral density in patients with type 2 diabetes mellitus

Vasilkova Olga , Mokhort Tatiana

Aim: To clarify the contribution of leptin to bone mineral density (BMD) in men with type 2 diabetes mellitus (DT2).Materials: We screened 168 Belorussian men aged 50–65 years. Plasma TC, HDL-C, LDL-C, VLDL-C, TG concentrations, HbA1c, IRI, CRP, total testosterone were assessed. BMD was evaluated using dual-energy X-ray absorptiometry (DXA). BMD was expressed as a T score. All statistical analyses were performed using SPSS v11.0 software....

ea0022p72 | Bone/Calcium | ECE2010

Study implications osteoporosis in gonadal disgenesias

Bistriceanu Iulia , Preda Magda Elvira , Bistriceanu Marian , Putinelu Liliana , Bondari Simona , Covei Aurora

All the defects of gonad formation during intrauterine development have been grouped under the name of gonadal disgenesias. Disturbances of the whole body appears in gonadal disgenesias, the disruption process of sexualization remaing the major event. In the absence or scarcity oestrogen, progesterone or androgens, hypogonadal sexoidoprive osteoporosis develops.Objectives: Early diagnosis of gonad disgenesias; study of bone mineral metabolism alterations...

ea0022p73 | Bone/Calcium | ECE2010

Bone mineral density study and biochemical markers of bone turnover in premature ovarian failure

Bistriceanu Iulia , Preda Magda Elvira , Bistriceanu Marian , Putinelu Liliana , Bondari Simona , Covei Aurora

Objectives: The premature ovarian failure (the poor ovaries’ syndrome) is characterized by the ovaries inability to normally sexualize, due to a poor sexoidogenetic device (low gonocyte population).Analysis of subjective and objective clinical criteria of patients with premature ovarian failure, early diagnosis of the premature ovarian failure, establish the etiology of premature ovarian through basal and dynamic hormones evaluation, assesment of pr...

ea0022p74 | Bone/Calcium | ECE2010

Delayed puberty and bone turnover biochemical markers

Bistriceanu Marian , Bistriceanu Iulia , Preda Magda Elvira , Bondari Simona , Covei Aurora , Putinelu Liliana

Background: Delayed puberty means the absence of secondary sexual characters until the age of 16 or the lack of puberty development until the limit of +2DS regarding the age when the puberty normally begins at considered population. Considering the major ethiological factor implied in delayed puberty, three mechanisms can be distinguished: hypothalamic, hypophyseal and gonadal. Osteoporosis depends mainly on the deficiency of one or of all sexual hormones, arised during the on...

ea0022p75 | Bone/Calcium | ECE2010

Structural heart disease in osteogenesis imperfecta: a case–control study

Guardiola Patricia Diaz , Jimenez Vanesa Bonilla , Falero Jesus Saavedra , Vela Maria Teresa Alberca , Bolanos Paloma Iglesias , de Paz Isabel Pavon

Background: Osteogenesis imperfecta (OI) is a few frequent disease with abnormal synthesis of type 1 collagen. That affects skeletal but also extra-skeletal tissues. Aortic root (AR) dilatation and valvular dysfunction have been described. Other studies, to estimate the size of the AR, index it by the body surface area (BSA), however, although these patients are shorter their internal organs have a relatively normal growth, so we could find overestimated AR values. Therefore, ...

ea0022p76 | Bone/Calcium | ECE2010

Osteomalacia: important cause of bone loss in a patient with inflamatory bowl disease: case report

Ghemigian Adina , Popescu Irina , Petrova Evghenia , Neacsu Elena , Dumitrache Constantin

Bone densitometry (DEXA) is the best method available today for diagnosing low bone density. However, DEXA is not able to differentiate osteoporosis from osteomalacia. The definitive diagnosis of osteomalacia is made by bone biopsy – rarely used in medical practice – which shows excess unmineralized bone. Tests of blood and urine may also be helpful: concentration of serum and urinary calcium and phosphorus, 25-hydroxyvitamin D and parathyroid hormone b...

ea0022p77 | Bone/Calcium | ECE2010

The effect of zoledronic acid on serum homocysteine, folate and vitamin B12 in patients with Paget's disease of bone

Polyzos Stergios , Anastasilakis Athanasios , Efstathiadou Zoe , Litsas Ioannis , Kita Marina , Panagiotou Athanasios , Papatheodorou Athanasios , Arsos Georgios , Moralidis Efstratios , Barmpalios Georgios , Zafeiriadou Efthimia , Terpos Evangelos

Purpose: High serum homocysteine (HCY) and indirectly deficiency of folate and/or vitamin B12 stimulate bone resorption and adversely affect collagen cross-linking. The aim of this study was the evaluation of serum levels of HCY, folate and vitamin B12 in patients with Paget’s disease of bone (PDB) and the effect of zoledronic acid (ZOL) on their serum levels.Methods: This was a prospective open-label cohort study, with a control arm at baseline. Ni...

ea0022p78 | Bone/Calcium | ECE2010

Angiotensin converting enzyme I/D and M235T angiotensinogen gene polymorphism in patients with acromegaly

Bucuras Dana , Grigoras Dorin , Anastasiu Doru , Poenaru Dan

Backgound: ESRD is associated with a sustained decrease in bone mineral density compared with aged-matched healthy controls. DXA is the standard noninvasive method to asses BMD. QUS is inexpensive, mobile, easy to perform, radiation free, recognize for screening abilities and risk fracture prediction in normal population. This study assessed the ability of QUS versus DXA in determine low bone mass in haemodialised population.Materials and methods: Patien...

ea0022p79 | Bone/Calcium | ECE2010

Cutoff point, upper and lower QUS parameters values in diagnosing demineralisation in cases with ESRD

Bucuras Dana , Poenaru Dan , Golea Ovidiu

Background: The British Society for Osteoporosis proposed a method for comparing different diagnostic measurements for BMD. It defines the upper and the lower limit for the investigated assay, that will identify osteoporosis with a sensitivity of 90% (the upper limit) and a specificity of 90% (the lower limit), compared with the defined golden standard method, mainly DXA for spine or hip. This rationale generate small number of false positive or negative results.<p class="...

ea0022p80 | Bone/Calcium | ECE2010

Secondary hypoparathyroidism in thalassaemia and sickle cell anaemia

Thisiadou Katerina , Karamouzis Ioannis , Arampatzi Stella , Chalvatzi Kiriaki , Hasapopoulou Eleni , Michailidou Despoina

Background: The diagnosis of hypoparathyroidism, a clinical situation characterised by reduced production of parathyroid hormone despite the low calcium level, depends on patient’s anamnesis, clinical aspect and the biochemical parameters.Thalassaemia, an inherited autosomal recessive blood disease, caused by the reduced capacity of erythroblasts to synthesize one of the chains that build up hemoglobine. The combination of transfusion and chelation ...

ea0022p81 | Bone/Calcium | ECE2010

Abnormalities in calcium, phosphorus and parathyroid hormone in patients with end stage chronic kidney disease on hemodialysis

Thisiadou Katerina , Karamouzis Ioannis , Arampatzi Stella , Tsolakidou Alexandra , Sioulis Athanasios , Michailidou Despoina

Introduction: The decline of renal function is closely associated to increased parathyroid hormone secretion, resulting to secondary hyperparathyroidism because of: 1) hypocalcemia; 2) hyperphosphatemia; 3) reduced activity of calcitriol; 4) skeletal resistance to the calcemic action of parathyroid hormone (PTH) and 5) reduced secretion of the calcium-sensing receptor (CaSR) in the parathyroid glands.The retention of phosphorus is considered to take an i...

ea0022p82 | Bone/Calcium | ECE2010

An unusual cause of life-threatening hypercalcaemia treated with haemodialysis

Thefanoyiannis Panos , Loh Vooi Lee , Seal Leighton J

We present a case of a 71-year-old Jamaican man who presented with a 4 weeks history of backache, lethargy, night sweats, decreased appetite, and weight loss. There was no significant medical history.Physical examination revealed tachypnoea, sinus tachycardia with evidence of short QT interval on the ECG, generalised lymphadenopathy with firm, rubbery glands up to 3×3 cm in diameter. Arterial blood gases were consistent with type 1 respiratory failu...

ea0022p83 | Bone/Calcium | ECE2010

The markers of bone remodelling in postmenopausal osteoporosis

Gurban Camelia , Zosin Ioana , Balas Melania , Gotia Smaranda , Gotia Laura , Drugarin Doina

The aim of the study: The paper analyzes the levels of soluble receptor activator of nuclear factor-κB ligand-(sRANKL), osteoprotegerin (OPG), bone alkaline phophatase (BAP), osteocalcin (BGP), estradiol, serum and bone levels of zinc [Zn(2+)], magnesium [Mg(2+)], calcium [Ca(2+)], phosphate [HPO4(2−)], and their correlation with bone mineral density (BMD).Material and method: The study included 74 p...

ea0022p84 | Bone/Calcium | ECE2010

Effect of strontium ranelate on vertebral pain syndrome in postmenopausal women with systemic osteoporosis treatment

Povoroznyuk Vladyslav , Dzerovych Nataliia , Orlyk Tetyana

Aim: To evaluate the effect of strontium ranelate in treatment of systemic osteoporosis in postmenopausal women.Materials and methods: There were examined 82 postmenopausal women with systemic osteoporosis (average age 58.4±4.5 years). Evaluation of pain syndrome and level of physical activity was carried out with VAS (the questionnaire developed by the ‘Servier’ company). Bone mineral density (BMD) was determined by means of dual-energy X...

ea0022p85 | Bone/Calcium | ECE2010

Giant mediastinal parathyroid adenoma, a rare cause of severe acute hyperparathyroidism

Maqdasy Salwan , Desbiez Francoise , Robu Elena , Batisse Marie , Roche Beatrice , Chadeyras Jean Baptiste , Tauveron Igor

Introduction: Ectopic parathyroid adenoma is a rare cause of primary hyperparathyroidism, it accounts for 10% of parathyroid adenomas.Observation: A 56 years old man with no past medical history developed sudden acute renal failure after few weeks of fatigability, polydypsia and emesis. Hypercalcemia of 4.20 mmol/l (2.2–2.5 mmol/l), serum creatinine of 306 mmol/l, hypophospatemia 0.72 mmol/l (0.80–1.5 mmol/l) and high alkaline phosphatase 205 I...

ea0022p86 | Bone/Calcium | ECE2010

Mandibular radiomorphometric indices as predictors of osteopenia and osteoporosis in postmenopausal women

Sheikholeslami Homayoun , Tofangchiha Maryam , Rastegary Samaneh , Sheikholeslami Sara

Introduction: Osteoporosis affects a large percentage of the elderly population. Since the disease is preventable, diagnostic techniques are of major importance. Furthermore, the dentist is the most regularly visited doctor in this population and panoramic radiographs are the most frequently used imaging modalities for these patients. The purpose of this study was to evaluate the radiomorphometric indices on panoramic radiographs of post-menopausal females.<p class="abstex...

ea0022p87 | Bone/Calcium | ECE2010

Asymptomatic primary hyperparathyroidism: current indications for final solution

Siprova Helena , Frysak Zdenek

Primary hyperparathyroidism (PHPT) belongs to the most common endocrine disorders. It is increasingly reported in patients without any symptoms and hypercalcemia. In the 3rd international workshop on asymptomatic PHPT (Orlando 2008) the normocalcemic PHPT was recognised as a stand-alone entity that needs more attention.Aim: The purpose of this study is to analyse data from patients with normocalcemic asymptomatic PHPT and to create an effective source da...

ea0022p88 | Bone/Calcium | ECE2010

Vitamin D and calcium status in women with postmenopausal osteoporosis

Novakovic-Paro Jovanka , Kovacev-Zavisic Branka , Medic-Stojanoska Milica , Bajkin Ivana , Icin Tijana , Todorovic-Djilas Ljiljana

Many studies show insufficient and inadequate vitamin D and calcium levels in postmenopausal women with osteoporosis, thus emphasising the need for supplementation therapy.Aim of the study: To determine vitamin D (25(OH)D) and ionised calcium levels in women treated for postmenopausal osteoporosis at our Clinic in the course of year 2009.Materials and methods: We prospectively followed up 116 women at the age of 59.38±5.55 (mi...

ea0022p89 | Bone/Calcium | ECE2010

Comparison of alendronate and raloxifene as a medical treatment option in patients with primary hyperparathyroidism

Akbaba Gulhan , Isik Serhat , Tutuncu Yasemin , Ozuguz Ufuk , Berker Dilek , Guler Serdar

Introduction: Primary hyperparathyroidism (pHPT) is the most frequent cause of hypercalcemia in ambulatory patients. Most persons have no symptoms, and pHPT usually is diagnosed after an elevated serum calcium (Ca2+) level is found incidentally. Parathyroidectomy is the definitive treatment for pHPT. There have been several different approaches to the medical management of pHPT. Our aim in this study is to compare alendronate sodium (ALN) and raloxifene (RLX) effici...

ea0022p90 | Bone/Calcium | ECE2010

Primary hyperparathyroidism: retrospective evaluation

Santos Jacinta , Paiva Isabel , Barros Luisa , Vieira Alexandra , Alves Marcia , Gouveia Sofia , Carvalheiro Manuela

Introduction: Primary hyperparathyroidism (PHP) results from an excessive secretion of parathyroid hormone (PTH), typically leading to hypercalcaemia. This disorder is more common than previously expected, since it is frequently diagnosed in asymptomatic patients.Objectives: To characterize a group of patients with PHP, in what concerns to: age, clinical presentation, biochemical and imaging evaluation, treatment and evolution.Pati...

ea0022p91 | Bone/Calcium | ECE2010

Long-term follow-up of the changes in serum 25-hydroxivitamin D to oral treatment with vitamin D3 in patients with postmenopausal osteoporosis

Grigorie Daniel , Sucaliuc Alina , Ivan Mirela , Neacsu Elena , Diaconescu Alina

The oral dosing with cholecalciferol needed to achieve and maintain optimal serum concentration 25-hydroxyvitamin D (25OHD) is still controversial.This study reports on the efficacy of supplementation with oral vitamin D3 1000 U/day for 3–18 months on serum 25OHD levels in 87 ambulatory patients with postmenopausal osteoporosis (mean age 63.5 years). Serum 25OHD, parathyroid hormone (PTH), calcium (serum, urine), phosphate, alkaline phosphatase and ...

ea0022p92 | Bone/Calcium | ECE2010

Management of primary hyperparathyroidism in Spain: a national survey

Torres Manuel Munoz , on behalf of Calcium Study Group

Background: At the Third International Workshop on asymptomatic primary hyperparathyroidism (PHPT), recent data on the disease were reviewed, but limited information of the PHPT management in Europe is available.Methods: We performed an online questionnaire survey in hospital endocrinology services to determine knowledge of current PHPT recommendations and its management in the clinical practice during 2009 Spain.Results: Ninety-ni...

ea0022p93 | Bone/Calcium | ECE2010

Glucocorticoid replacement therapy and vertebral fractures in hypopituitary adult males with GH deficiency

Mazziotti Gherardo , Porcelli Teresa , Bianchi Antonio , Cimino Vincenzo , Mejia Carola , Patelli Ilaria , Fusco Alessandra , Giampietro Antonella , De Marinis Laura , Giustina Andrea

GH deficiency (GHD) and excess of glucocorticoids are associated with increased risk of fragility fractures. Most adult GHD patients have other pituitary deficiencies, but it is unclear whether these deficiencies or their overreplacement therapies may influence the bone disease occurring in GHD. The aim of this study was to evaluate whether the prevalence of vertebral fractures may be influenced by glucocorticoid replacement therapy in hypopituitary males with GHD. We studied ...

ea0022p94 | Bone/Calcium | ECE2010

Dissimilar PTH, gastrin, and ionized calcium response to oral peptones in normocalcemic primary hyperparathyroidism, hypercalcemic primary hyperparathyroidism and normal subjects

Bevilacqua Maurizio , Invernizzi Marco , Carda Stefano , Cisari Carlo

It has been hypothesized that primary hyperparathyroidism (PH) has a biphasic disease course. During the first phase hypercalcemia is not yet present. Subsequently, the second phase starts with the development of hypercalcemia. In an attempt to identify differences in the calcium regulating hormonal handling in the clinical setting, we evaluated the hormonal responses of gastrin, PTH, phosphate and ionized calcium to oral peptones (a mixture containing L-amino acids with known...

ea0022p95 | Bone/Calcium | ECE2010

Cross-validated calculation procedure to assess the cholecalciferol loading dose for rapid correction of vitamin D deficiency

van Groningen Lenneke , van Sorge Adriaan , Telting Darryl , Giessen Astrid , de Boer Hans

Introduction: Vitamin D deficiency is very common in Northern Europe. Recently, we developed an equation to calculate the vitamin D deficit, based on the serum 25-OH vitamin D3 (25OHD3) level and body weight: vitamin D deficit (IU)=40×(75−serum 25OHD3)×body weight. The calculated deficit gives the amount of cholecalciferol that is required to raise the serum 25OHD3 level to the target of 75 nmol/l.<p class="abstex...

ea0022p96 | Bone/Calcium | ECE2010

Hypoparathyroidism mimicking ankylosing spondylitis

Gedik Arzu , Yilmaz Merve , Eraydin Ayten , Gunes Mustafa , Eraslan Sevinc

Idiopathic hypoparathyroidism (IHP) is an uncommon disease in which soft tissue calcifications may be seen. We report a case with IHP with asymptomatic hypocalcemia and features of ankylosing spondylitis (AS).Case: A 58-year-old male patient was referred to our department due to incidentally discovered hypocalcemia when admitted with blurred speech, gait and posture abnormalities. He had had a generalized convulsion 19 years ago. On physical examination,...

ea0022p97 | Bone/Calcium | ECE2010

Multiple osteoporotic fractures in myasthenia gravis patient receiving short-term prednisolone therapy

Maric Andreja , Belovari Mirna , Palasek Jasna Mundjar , Pevec Damira , Mikolaj Maja , Vrkljan Milan

A 74-year-old female patient was admitted to Department of Neurology due to bilateral ptosis and diplopia she suddenly felt 3 weeks prior to admission. She also complained of weakness, dizziness and swallow disability. Her medical history revealed hypertension and minor depressive disorder. Body mass index was 32 kg/m2. Electrocardiogram, chest X-ray and complete laboratory findings were normal, except elevated TSH, so levothyroxin was included in therapy. She had p...

ea0022p98 | Bone/Calcium | ECE2010

Teriparatide in the treatment of severe osteoporosis: results of a multicenter prospective study

Payer Juraj , Tomkova Sona , Killinger Zdenko , Jackuliak Peter , Vanuga Peter , Letkovska Alexandra , Masaryk Pavol , Kmecova Zlata

Introduction: Teriparatide (TPTD) is a recombinant aminoterminal fragment (1–34) of the human parathyroid hormone (PTH), which has a predominantly stimulating effect on bone formation. We report results of an 18-month prospective multicenter study with daily s.c. application of 20 μg of teriparatide in 85 elderly women with severe osteoporosis, the efficacy, safety and compliance of the treatment.Outcomes: The primary outcomes were defined as c...

ea0022p99 | Bone/Calcium | ECE2010

Vitamin D deficiency and comorbidity

Kostoglou-Athanassiou Ifigenia , Chronaiou Aikaterini , Athanassiou Panagiotis , Michou Aikaterini , Stefanopoulos Dimitris , Badila Razvan Alexandros , Terzi Thomais , Karfi Areti

Vitamin D deficiency is increasingly recognized today having taken the form of a modern epidemic. Vitamin D, being synthesized in the skin under the effect of ultraviolet light has been originally thought of as occurring only in areas of the world where people are not exposed to the sun. However, it has recently been observed that vitamin D deficiency exists even in sunny areas. Recent observations suggest that vitamin D deficiency is related to significant comorbidity, specif...

ea0022p100 | Bone/Calcium | ECE2010

Vitamin D status among adults in the Aegean region of Turkey

Hekimsoy Zeliha , Dinc Gonul , Kafesciler Sabriye , Onur Ece , Guvenc Yesim , Pala Tumer , Guclu Feyzullah , Ozmen Bilgin

Vitamin D is a lipid-soluble hormone found in certain foods and synthesized from precursors in the skin when exposed to ultraviolet light. Vitamin D plays a critical role in bone metabolism and many cellular and immunological processes; and low levels have been associated with several chronic and infectious diseases. Vitamin D status is assessed by measuring the concentration of serum 25-hydroxy vitamin D (25(OH) D). Vitamin D deficiency is reported to be common worldwide, but...

ea0022p101 | Bone/Calcium | ECE2010

Fine needle aspiration of parathyroid gland with PTH analysis in washouts: is it worthy?

Melo Miguel , Ribeiro Cristina , Paiva Sandra , Vieira Alexandra , Carrilho Francisco , Carvalheiro Manuela

Introduction: Primary hyperparathyroidism (PHPT) is the most common cause of hypercalcaemia in the outpatient setting. Surgical remove of an adenoma or hyperplastic glands results in cure, but an accurate localization, preoperative whenever possible, is essential for success. Taking into consideration that parathyroid carcinoma is a rare event, FNA of parathyroid glands, complemented by PTH measurement in washouts (FNA/PTH), may be a useful tool in the diagnostic workout.<...

ea0022p102 | Bone/Calcium | ECE2010

Positive effect of human adipocyte-secreted factors on human osteoblast proliferation and the OPG/RANKL ratio in vitro

Kuhn Markus C , Scherbaum Werner A , Schinner Sven

Objectives: Reduced bone mass and compromised bone quality characterise osteoporosis. A positive relationship of the body-mass-index or the body fat mass and the bone density has been reported by several clinical studies. However, it is not clear whether this observation is attributable to higher mechanical stress or whether adipocytes secrete products that directly affect the bone structure.Methods: Isolation of human primary adipocytes to generate fat-...

ea0022p103 | Bone/Calcium | ECE2010

Tumoral calcinosis likely due to end-organ resistance to FGF23

Cianferotti Luisella , Vignali Edda , Cetani Filomena , Galli Giulia , Giacomelli Tamara , Pinchera Aldo , Marcocci Claudio

Tumoral calcinosis is a rare autosomal recessive disease characterized by hyperphosphatemia due to increased renal phosphate reabsorption leading to soft tissue calcifications. The levels of fibroblast growth factor 23 (FGF23), a hormone required for normal renal phosphate reabsorption, are typically low in the classic form of the disease due to homozygous missense mutations in FGF23 or in the UDP-Nacetyl-alpha-D galactosamine:polypeptide N-acetylgalactos...

ea0022p104 | Bone/Calcium | ECE2010

Wermer syndrome revealed by primary hyperparathyroidism: a case report

Nadia Mchirgui , Ali Insaf Hadj , Karima Khiari , Hela Cheikhrouhou , Youssef Lakhoua , Nejib Ben Abdallah

Multiple endocrine neoplasia type 1 (MEN1) is a rare but misleading disease. The diagnosis is evocated when two main lesions are present (parathyroid, pituitary gland, endocrine pancreas tumor: Gastrinoma). We studied a 36 year-old woman hospitalized in orthopedics for a neck femur fracture. A hypercalcaemia (Ca++=2.84 mmol/l) with elevated PTH=500 pg/ml were discovered before intervention. The bone biopsy concluded to primary hyperparathyroidism lesions.<p class="abstext"...

ea0022p105 | Bone/Calcium | ECE2010

Severe primary hyperparathyroîdism related multiple clear cell adenome

Karima Khiari , Ali Insaf Hadj , Youssef Lakhoua , Nadia Mchirgui , Hela Cheikhrouhou , Abdallah Nejib Ben

We report a 25 years old man who admitted in our department for primary hyperparathyroidism. He has previously been diagnosed with urolithiasis in 2006 and two pathological fracture of the humerus in 2009.Physical exam was normal laboratory findings showed hypercalcemia (4.06 mmol/l) associated to a high parathyroid hormone level (PTH: 1930 pg/ml).Ultrasound examination of the neck showed two enlarged parathyroid adenoma.<p cla...

ea0022p106 | Bone/Calcium | ECE2010

Osteocalcin, OPG and RANKL circulating levels in adolescent idiopathic scoliosis

Popa Oana , Chiru Anton Mariana , Vladoiu Susana , Manda Dana , Ianas Olga

Background: Idiopathic scoliosis is a pathological entity of unknown etiology, characterized by a three-dimensional deformity of the spine and a low bone mass. The exact mechanism of bone loss in idiopathic scoliosis is unknown yet. However is well known that RANKL is a potent stimulator of bone resorption by binding receptor activator of nuclear factor-kB (RANK) in the osteoclasts cell membrane. OPG is a decoy receptor for RANKL, which interferes with RANKL/RANK binding and i...

ea0022p107 | Bone/Calcium | ECE2010

Parathyroid FNA with PTH determination as a tool in primary hyperparathyroidism diagnosis – case report

Idriceanu Jeanina , Ionescu Lidia , Miron Claudia , Balcan Roxana , ElMekkaoui Safae , Vasiliu Ioana , Mogos Voichita , Vulpoi Carmen

I fine-needle aspiration (FNA) is the gold standard in thyroid nodules management, but it is less common in the evaluation of parathyroid nodules. When imagery fails to localize a parathyroid adenoma, morphological and functional investigations, like FNA of the suspected area and scintigraphy may be useful. We present the case of a 58 years-old woman, menopaused at 47 years, who consulted for lombalgia. Vertebral DXA confirmed osteoporosis (Tscore −3.8). She was not trea...

ea0022p108 | Bone/Calcium | ECE2010

Bone turnover, serum osteoprotegerin and soluble receptor activator of nuclear factor-Kβ ligand levels in patients with hyperthyroidism

Hekimsoy Zeliha , Kafesciler Sabriye , Taneli Fatma , Aras Feray , Ozmen Bilgin , Guclu Feyzullah

Osteoprotogerin (OPG) and the receptor activators of nuclear factor-kβ (RANK) and nuclear factor-kβ ligand (RANKL) play an important role in bone metabolism. RANKL binds to RANK, which is expressed by osteoclasts, whereas OPG acts as its decoy receptor, blocking the RANK–RANKL interaction.The aim of our study was to evaluate bone turnover parameters (serum calcium, phosphorus, alkaline phosphatase, parathormone, osteocalcine, 24-...

ea0022p109 | Bone/Calcium | ECE2010

Primary hyperparathyroidism at pregnancy

Yorulmaz Goknur , Kebapci Nur , Onbasi Kevser , Efe Belgin , Akalin Aysen

Primary hyperparathyroidism during pregnancy is a rare condition associated with a high frequency of complications in both mother and fetus. Operation in the second trimester is offered. Here we report about a case with hyperemesis and hyperparathyroidism during routine laboratory examinations.A 30-years-old pregnant woman attendant our policlinic with hyperemsis gravidarum. Her calcium and parathormone level were elevated; 11.6 mg/dl and 135 pg/ml, resp...

ea0022p110 | Bone/Calcium | ECE2010

Comparative evaluation of bone density measurement with DXA or quantitative ultrasound of bone in the diagnosis and treatment monitoring of osteoporosis – a field study

Knauerhase Andreas , Beier Susanne , Zingler Christiana , Tolkemitt Gerritt , Hampel Rainer

Question: Can be reliably diagnosed osteoporosis with quantitative ultrasound of bone? Can the therapeutic progress of a specific osteoporosis therapy reliably judged by that?Patients and methods: Three hundred and twenty patients were enrolled between July 1999 and October 2004. All patients were studied in the osteoporosis clinic at time 0, after 1, 2 and 3 years. BMD was done with Hologic QDR-1000 (low back or hip) and the Osteometer DTU one (paramete...

ea0022p111 | Bone/Calcium | ECE2010

Osteoporosis and osteopenia in patients after the organ transplantation

Brunova Jana

Background: Survival of patients after the transplantation (Tx) of solid organs is improving. Osteoporosis and bone fractures belong to their long-term complications. The contributing factors are disturbances of bone metabolism in pre-transplant period and immunosuppressive therapy including corticosteroids after the transplantation.Patients and methods: We investigated the prevalence of osteoporosis and osteopenia in 248 diabetic patients after the Tx o...

ea0022p112 | Bone/Calcium | ECE2010

Risk of vertebral fractures in osteoporotic women: definition of a clinically relevant scale of risk

Fusco Alessandra , Pola Enrico , Mormando Marilda , Colangelo Debora , Aurelio Nasto Luigi , Bianchi Antonio , Ambrogio Logroscino Carlo , De Marinis Laura

Introduction: Osteoporosis is a disease characterized by a low bone mass and the development of nontraumatic fractures, most commonly in the spine. However, bone mineral density (BMD) alone is not completely satisfactory in vertebral fracture risk assessment.Aim of the study: To identify clinical and laboratoristic factors associated with an increased risk of vertebral fractures in osteoporotic Caucasian women and to define a new clinically relevant scal...

ea0022p113 | Bone/Calcium | ECE2010

Diagnostic challenge in child’s bone cystic lesions

Cornianu Marioara , Micle Ioana , Golu Ioana , Vlad Mihaela , Dema Alis , Taban Sorina , Muresan Anca , Lazureanu Codruta

Introduction: Primary hyperparathyroidism (PHP) affects predominantly the adult age (incidence 1/10 000) and it is unusual.The aim of the study: Is to present a rare pathology in a child, which implied interdisciplinary collaboration.Material and method: We present a teenager girl of 16 years old, diagnosed with osteomalacia after a thoracic and pelvis trauma, based on knee and pelvis radiographs (diffuse bone demineralization, tra...

ea0022p114 | Bone/Calcium | ECE2010

Male osteoporosis of multiple drug aetiology

Klangos Georgios , Athanassiou Panagiotis , Kostoglou-Athanassiou Ifigenia , Chronaiou Aikaterini , Michou Aikaterini , Stefanopoulos Dimitris , Kotanoglou Stylianos , Karfi Areti

Male osteoporosis is a reality and in many cases appears to be secondary to drug administration. Many pharmaceutical agents are related to the appearance of osteoporosis, affecting bone metabolism by multiple and diverse mechanisms.The aim was to describe the case of a patient who presented with male osteoporosis of multiple drug aetiology.A patient, male aged 52 years, an orthodox priest, presented with spontaneous fractures and d...

ea0022p115 | Bone/Calcium | ECE2010

Extraosseous effects of raloxifene in osteoporotic postmenopausal women

Sebastian-Ochoa Arantzazu , Fernandez-Garcia Diego , Reyes Garcia Rebeca , Munoz Torres Manuel

Raloxifene is a selective estrogen receptor modulator which has shown to decrease bone resorption, increase bone density and reduce vertebral fracture rate in women with postmenopausal osteoporosis. Recent studies have shown a decrease on breast cancer incidence after raloxifene treatment. Although the mechanism is not clear, its mixed agonist and antagonist properties in different tissues could partially explain this effect.Objective: To evaluate the ef...

ea0022p116 | Bone/Calcium | ECE2010

Polyunsaturated fatty acids omega-3, but not the omega-6, stimulates the differentiation to osteoblasts of mesenchymal stem cell

Casado-Diaz Antonio , Santiago-Mora Raquel , Manso Pilar , Manuel Quesada Jose

The compounds derived from the oxidative stress and lipid peroxidation stimulate the bone loss, in part because they enhance the adipogenesis and blunt the osteoblastogenesis from mesenchymal stem cell (MSC), increasing the marrow adiposity that accompanies the osteoporosis. The consumption of omega-3 seems to have a protective effect on bone. This effect has been associated with the production of 15-hydroxy-eicosapentaenoic acid and 17-hydroxy-docosahexaenoic...

ea0022p117 | Bone/Calcium | ECE2010

Evaluation of age and sex influence on the morphometric parameters of vertebrae in densitometric morphometry – results of EPOLOS study

Skowronska-Jozwiak Elzbieta , Lewinski Andrzej , Pludowski Pawel , Karczmarewicz Elzbieta , Lorenc Roman

Vertebral morphometric X-ray absorptiometry (MXA) is a new tool developed to evaluate the presence of vertebral fractures – main symptoms of osteoporosis. The study aimed at comparing selected morphometric parameters of vertebrae in men and women in various age groups. 965 healthy persons have been involved in the study: 616 female and 349 male, their age ranging from 18 to 79 years. Lateral densitometric scans of the thoracic-lumbar spine were made using Expert-XL densit...

ea0022p118 | Bone/Calcium | ECE2010

Primary hyperparathyroidism diagnosis – new insights of an old dilemma

Vulpoi Carmen , Stefanescu Cipriana , Ionescu Lidia , Crumpei Felicia , Vasiliu Ioana , Balcan Roxana , Idriceanu Jeanina , Mogos Voichita

Primary hyperparathyroidism (PHPT) is a relatively frequent problem in clinical endocrine practice. Minimally invasive parathyroid surgery is the treatment of choice but requires precise preoperatory localization. The most commonly investigation methods are ultrasonography and scintigraphy, but they are not always diagnostic. PTH assay of the aspirate from an ultrasound-guided fine-needle aspiration (USFNA) may confirm the location of pathological parathyroid tissue. The aim o...

ea0022p119 | Bone/Calcium | ECE2010

PTH treatment in adult hypophosphatasia: significant increase in S-AP, improvement of pain and fracture healing in two siblings with ALPL gene mutations G339R and E191K

Schalin-Jantti Camilla , Valimaki Matti , Mornet Etienne

Background: Hypophosphatasia (HPP) is characterized by low serum alkaline phosphatase (S-AP) activity due to loss-of function mutations in the ALPL gene. A hallmark of adult HPP is painful, slowly healing metatarsal and femur stress fractures. There is no treatment for the disease but beneficial effects of parathyroid hormone (PTH) treatment was previously demonstrated in one patient. It is unclear how parathyroid hormone (PTH) can stimulate S-AP despite loss-of functio...

ea0022p120 | Bone/Calcium | ECE2010

Estradiol and testosterone levels in diabetic type 2 men with low bone density and osteoporosis

Mascarenhas Mario Rui , Barbosa Ana Paula , Nobre Ema , Goncalves Ana , Simoes Vera , Camolas Jose , Carvalho Maria Raquel , Ferreira Joana , Vieira Joao , Pinto David Santos , Bicho Manuel , do Carmo Isabel

Osteoporosis and diabetes mellitus type 2 (DM2) have severe health consequences, with high morbidity and mortality risks.Aims: To study the differences of the sex steroid hormones levels and the free androgen index (FAI) in DM2 men with low BMD and osteoporosis and their relationships with BMD.Materials and methods: In 317 men with DM2, the BMD (g/cm2) was evaluated at the lumbar spine (L1-L4), at t...

ea0022p121 | Bone/Calcium | ECE2010

The circadian rhythm of bone resorption: comparison between patients treated with teriparatide and patients with primary hyperparathyroidism

Luchavova Maria , Raska Ivan , Michalska Dana , Zikan Vit

Parathyroid hormone (PTH) has a biphasic effect on bone cells and can induce opposing responses resulting in both net bone loss and net bone formation. Patients with primary hyperparathyroidism (PHPT) lose the circadian rhythm for PTH and bone mass decreases. PTH administered intermittently resulting in increase in bone mass. We studied the differences in the circadian variability of bone turnover markers between women with PHPT and women with postmenopausal osteoporosis treat...

ea0022p122 | Bone/Calcium | ECE2010

Primary hyperparathyroidism: laboratory associations and thyroid pathologies

Agbaht Kemal , Eraslan Emrah , Karaarslan Ozlem , Gullu Sevim

Background: Diagnosis of primary hyperparathyroidism (PHP) is sometimes challenging and needs supportive evidence. We aimed to document laboratory findings (ratio of calcium clearance to creatinine clearance, ratio of phosphorus clearance to creatinine clearance, serum chloride to phosphorus ratio, serum alkaline phosphatase) and thyroid pathologies associated with established PHP that may provide supplementary clues to the diagnosis.Methods: We document...