Searchable abstracts of presentations at key conferences in endocrinology
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12th European Congress of Endocrinology

Symposia

The role of oxidative stress in the development of the metabolic syndrome

ea0022s9.2 | The role of oxidative stress in the development of the metabolic syndrome | ECE2010

Macrophage dysfunction and insulin resistance

Kovanen Petri T

Obesity and associated insulin resistance are associated with increased numbers of infiltrating macrophages at various sites of white adipose tissue. The adipose tissue macrophages are considered to be a major cause of obesity-associated chronic low-grade inflammation. The macrophages present in adipose tissue secrete a wide variety of proinflammatory molecules including tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1)...

ea0022s9.3 | The role of oxidative stress in the development of the metabolic syndrome | ECE2010

Marked improvement of insulin resistance by reduced age intake; a non-pharmacologic, non-nutrient based intervention for type 2 diabetes

Vlassara Helen

The clinical efficacy of strict glucose control against risk of diabetic macrovascular complications, despite effective treatment, has been disappointing, pointing to non-glucose related etiologic factors. Elevated inflammatory advanced glycation end products (AGEs), or Glycotoxins, known to increase the incidence and severity of diabetic complications, are recently shown to impair insulin production and insulin actions, hence are involved in the etiology of diabetes and insul...