Searchable abstracts of presentations at key conferences in endocrinology
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12th European Congress of Endocrinology

ea0022oc2.1 | Thyroid | ECE2010

Calcitonin screening and pentagastrin testing: predictive value for diagnosis medullary carcinoma in nodular thyroid disease

Herrmann Burkhard , Schmid Kurt , Bockisch Andreas , Kemen Mathias , Mann Klaus

Context: Serum calcitonin (hCT) measurement may be useful for detecting medullary carcinoma (MTC), but the routine use of hCT and after pentagastrin stimulation to screen patients with nodular thyroid disease remains controversial.Patients: One thousand and seven patients (667 females, 440 males) with nodular thyroid disease and a mean age of 55±14 (mean±S.D.) years were included in the study. All patients did not have impaired r...

ea0022oc2.2 | Thyroid | ECE2010

Systemic sodium iodide symporter (NIS) gene transfer in hepatocellular carcinoma using EGF-receptor targeted non-viral gene delivery vectors

Klutz Kathrin , Schaffert David , Rodl Wolfgang , Willhauck Michael J , Cengizeroglu Arzu , Wunderlich Nathalie , Gildehaus Franz Josef , Wagner Ernst , Goke Burkhard , Ogris Manfred , Spitzweg Christine

We have recently demonstrated induction of tumor-selective accumulation and therapeutic efficacy of radioiodine in neuroblastoma tumors after systemic non-viral polyplex-mediated sodium-iodide-symporter (NIS) gene delivery.In the current study, we evaluated the efficacy of novel synthetic nanoparticle vectors based on linear polyethylenimine (LPEI), shielded by polyethylene glycol (PEG), and coupled with the synthetic peptide GE11 as an epidermal growth ...

ea0022oc2.3 | Thyroid | ECE2010

Allelic discrimination in the diagnosis of somatic BRAF V600E mutation on fine-needle aspiration biopsies

Buratto Mattia , Tagliati Federico , Trasforini Giorgio , Leoni Stefania , Rossi Roberta , degli Uberti Ettore C , Zatelli Maria Chiara

Many studies demonstrated that somatic BRAF gene mutation analysis increases diagnostic accuracy for papillary thyroid carcinoma (PTC), even from very small samples. The gold standard for point mutations research is direct sequencing, that implies DNA extraction, PCR with specific primers, sequencing reaction and run on an automatic sequencer. This is an expensive and time consuming method, and the possible contamination with wild-type DNA not coming from the nodule significan...

ea0022oc2.4 | Thyroid | ECE2010

Polyglandular autoimmunity in autoimmune thyroid disease behaves differently from polyglandular autoimmunity in type 1 diabetes

Wiebolt Janneke , den Boer Annette , Achterbergh Roos , Suelmann Britt , van der Leij Stephanie , de Vries Renske , van Haeften Timon

Aim: Patients with autoimmune thyroid disease (AITD) or type 1 diabetes (T1DM) are prone to develop other autoimmune diseases. This has led to the concept of autoimmune polyglandular syndromes (APS). It has been proposed that AITD and type 1 diabetes are both part of the same APS (subtype 2). This would imply that they associate with the same diseases. We evaluated whether the clustering of autoimmune antibodies differs between AITD and T1DM.Methods: Ant...

ea0022oc2.5 | Thyroid | ECE2010

Thyroid dysfunction related abnormalities in adiponectin and glucose metabolism before and after treatment

Ozdemir Didem , Dagdelen Selcuk , Usman Aydan

Objective: Thyroid dysfunctions have various effects on glucose and lipid metabolism. Adiponectin (ADP) is an adipokine decreased in obesity and insulin resistance. In this study, we aimed to investigate the role for ADP in thyroid dysfunction related changes in glucose and lipid metabolism.Methods: Newly diagnosed overt hypothyroid (n=20) and thyrotoxic (n=23) adult patients with a body mass index (BMI)<30 kg/m2 were include...

ea0022oc2.6 | Thyroid | ECE2010

Percutaneous laser ablation (PLA) in non-functioning benign thyroid nodules: a 3-year follow-up study

Valcavi Roberto , Riganti Fabrizio , Bertani Angelo , Formisano Debora , Pacella Claudio M

Aim of the study: To evaluate efficacy and safety of ultrasound-guided percutaneous laser ablation (PLA) on benign thyroid nodule size reduction, thyroid function and autoimmunity.Methodology: This study was approved by local institutional review committee. All data are mean±S.D. Two hundred and ninety-eight euthyroid outpatients (F=241, M=57; age 50.7±12.0 years) with a benign thyroid nodule (volume 23.1±21.3 ml) causing ei...