Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2010) 22 P418

1Institut Gustave Roussy, Villejuif, France; 2Service d’Endocrinologie et des Maladies de la Reproduction, Kremlin Bicetre, France.


Context: Peritoneal carcinomatosis (PC) is a rare site of distant metastasis in patients with adrenocortical cancer (ACC). One preliminary study suggests an increase risk of PC after adrenalectomy through laparoscopic approach of ACC.

Objective: The objective of the study was to search for risk factors of PC including surgical approach. This was a retrospective cohort study conducted in an institutional practice.

Patients: Sixty-four consecutive patients with ACC seen at our institution between 2003 and 2009 were included. Mean tumor size was 132 mm. Patients had stage I disease in 2 cases, stage II in 32 cases, stage III in 7 cases, stage IV in 21 cases and unknown stage in 2 cases. Surgery was open in 58 cases and laparoscopic in 6 cases.

Results: PC occurred in 18 (28%) patients. It was present at initial diagnosis in 3 cases and occurred during follow-up in 15 cases. The only risk factor of PC occurring during follow-up was the surgical approach with a 4-year rate of PC of 67% (95CI, 30–90%) for laparoscopic adrenalectomy and 27% (95CI, 15–44%) for open adrenalectomy (P=0.016). Neither tumor size, stage, functional status, completeness of surgery or plasmatic level of op’DDD were associated with the occurrence of PC.

Conclusion: We found an increase risk of PC after laparoscopic adrenalectomy of ACC. Adrenal tumors bearing malignant characteristics preoperatively should be referred for open adrenalectomy.

Article tools

My recent searches

No recent searches.