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Endocrine Abstracts (2010) 22 P150

Cardiovascular endocrinology and lipid metabolism

Genetic polymorphisms associated with cardiovascular risk correlate with dyslipidaemia in healthy postmenopausal women

Dimitra Papadimitriou1, George Kaparos2, Dimitrios Rizos2, Eleni Armeni1, Maria Creatsa1, Andreas Alexandrou3, George Christodoulakos1 & Irene Lambrinoudaki1


12nd Department of Obstetrics and Gynecology, Aretaieio Hospital, University of Athens, Athens, Greece; 2Hormonal and biochemical Laboratory, Aretaieio Hospital, University of Athens, Athens, Greece; 31st Department of Surgery, Laiko Hospital, University of Athens Medical School, Athens, Greece.

Objective: To assess the impact of genetic polymorphisms associated with increased cardiovascular risk on the lipid profile in healthy postmenopausal women.

Methods: The study population consisted of 84 women between 49–69 years who had been menopausal for at least one year. The genetic polymorphisms examined were the following: Glycoprotein IIIa leu33pro, Apolipoprotein E2/E3/E4, Methylenotetrahydrofolate reductase ala222val, Apolipoprotein B arg3500gln, Paraoxonase 1 gln192arg, Plasminogen activator inhibitor 1 4G/5G, cholesterol 7 alpha hydroxylase A-204C and cholesterol ester transfer protein (TaqIB) B1/B2 polymorphism. Biochemical markers assessed were the following: Total cholesterol (TC), low-density Lipoprotein (LDL), high-density Lipoprotein (HDL), triglycerides (TGL), Apolipoprotein A (ApoA), Apolipoprotein B (ApoB) and Lipoprotein (a) (Lp(a)). Written informed consent was obtained by all participants. The local Institutional Review Board has approved the present study.

Results: Cholesterol ester transfer protein (TaqIB) B1/B2 polymorphism associates with low levels of HDL and ApoA (P=0.001, P=0.0001 respectively), while Glycoprotein IIIa leu33pro polymorphism is associated with suppressed levels of ApoB (P=0.019). A statistically significant positive association was observed between Apolipoprotein B arg3500gln polymorphism and levels of total cholesterol (P=0.032) and HDL cholesterol (P=0.048). Additionally, plasminogen activator inhibitor 1 4G/5G polymorphism was marginally associated with increased levels of triglycerides (P=0.058).

Conclusions: The presence of certain polymorphisms predisposes postmenopausal women to dyslipidaemia. Cholesterol ester transfer protein (TaqIB) B1/B2 polymorphism favours dyslipidaemia, while Glycoprotein IIIa leu33pro polymorphism has a positive impact on lipid profile in women after menopause. Apolipoprotein B arg3500gln polymorphism associates ambiguously with the lipid profile in postmenopausal women. Further studies are required to elucidate the significance of these genetic polymorphisms with respect to dyslipidaemia in postmenopausal women.

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