Endocrine Abstracts (2010) 22 P467

Serum lipocalin-2 as an insulin resistance marker in patients with polycystic ovary syndrome

Erman Cakal1, Mesut Ozkaya2, Yaprak Engin-Ustun3 & Yusuf Ustun3

1Department of Endocrinology, Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey; 2Department of Endocrinology, Sutcu Imam University Medical Faculty, Kahramanmaras, Turkey; 3Department of Obstetrics and Gynecology, Inonu University Medical Faculty, Malatya, Turkey.

Background: Our aim was to investigate levels of lipocalin-2 and its relationship with metabolic factors in women with polycystic ovary syndrome (PCOS).

Materials/subjects and methods: In this cross-sectional study, two groups of women were studied: group 1 consisted of women with PCOS (n=30), and group 2 consisted of control women with normal ovulatory function (n=30). The circulating levels of lipocalin were measured.

Results: Serum lipocalin was significantly higher in PCOS subjects. We found a close correlation between lipocalin and insulin, lipocalin and HOMA-IR, lipocalin and testosterone and lipocalin and DHEAS. A cut-off level of >39.54 ng/ml for serum lipocalin has a predictive value for insulin resistance of 81% sensitivity and 82.1% specificity.

Conclusion: In our study, lipocalin-2 levels were found to be significantly higher in women with PCOS compared to body mass index-matched controls. Serum lipocalin-2 may prove to be a useful marker for insulin resistance in patients with PCOS.

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